Recombinant Human ROR1 Protein, C-6His-Avi tagged, Biotinylated

Cat.No. : ROR1-10H
Product Overview : Biotinylated Recombinant Human Inactive Tyrosine-protein Kinase Transmembrane Receptor ROR1 isproduced by our Mammalian expression system and the target gene encoding Gln30-Glu403 is expressedwith a 6His, Avi tag at the C-terminus.
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Description : Receptor tyrosine kinase-like orphan receptor 1 (ROR1), also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases (RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids (aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. At developmental stage, it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
Source : Human Cells
Species : Human
Tag : C-6His-Avi
Protein Length : Gln30-Glu403
Endotoxin : Less than 0.1 ng/μg (1 EU/μg)
Storage Buffer : Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Shipping : Ambient
Gene Name : ROR1 receptor tyrosine kinase-like orphan receptor 1 [ Homo sapiens (human) ]
Official Symbol : ROR1
Synonyms : Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophictyrosine kinase; receptor-related 1; ROR1; NTRKR1
Gene ID : 4919
mRNA Refseq : NM_001083592
Protein Refseq : NP_001077061
MIM : 602336
UniProt ID : Q01973

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (4)

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What is the expression level of ROR1 in normal tissues. 11/28/2022

ROR1 is barely expressed in normal, differentiated and mature tissues, but is highly expressed in tumor tissues.

What are the effects of inhibiting ROR1 expression? 07/14/2022

Inhibit the expression of ROR1 can reduce the proliferation and migration ability of tumor cells.

What biological processes is ROR1 involved in? 12/26/2021

ROR1 is involved in the regulation of cell metabolism, proliferation, apoptosis, and differentiation.

What diseases is ROR1 involved in? 03/01/2021

ROR1 is involved in the study of breast, lung and ovarian cancers.

Customer Reviews (3)

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10/18/2022

    Customer service promptly feedback my requests, technical staff timely solve the problems that arise.

    08/13/2022

      Excellent after-sales service, solving many experimental problems.

      04/12/2021

        Fast and timely shipment helped me to get satisfactory experimental results in short time.

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