| Description : |
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
13.4 kDa |
| Protein Length : |
937 |
| AA Sequence : |
MHRPRRRGTRPPLLALLAALLLAAR GAAAQETELSVSAELVPTSSWNISS ELNKDSYLTLDEPMNNITTSLGQTA ELHCKVSGNPPPTIRWFKNDAPVVQ EPRRLSFRSTIYGSRLRIRNLDTTD TGYFQCVATNGKEVVSSTGVLFVKF GPPPTASPGYSDEYEEDGFCQPYRG IACARFIGNRTVYMESLHMQGEIEN QITAAFTMIGTSSHLSDKCSQFAIP SLCHYAFPYCDETSSVPKPRDLCRD ECEILENVLCQTEYIFARSNPMILM RLKLPNCEDLPQPESPEAANCIRIG IPMADPINKNHKCYNSTGVDYRGTV SVTKSGRQCQPWNSQYPHTHTFTAL RFPELNGGHSYCRNPGNQKEAPWCF TLDENFKSDLCDIPACDSKDSKEKN KMEILYILVPSVAIPLAIALLFFFI CVCRNNQKSSSAPVQRQPKHVRGQN VEMSMLNAYKPKSKAKELPLSAVRF MEELGECAFGKIYKGHLYLPGMDHA QLVAIKTLKDYNNPQQWTEFQQEAS LMAELHHPNIVCLLGAVTQEQPVCM LFEYINQGDLHEFLIMRSPHSDVGC SSDEDGTVKSSLDHGDFLHIAIQIA AGMEYLSSHFFVHKDLAARNILIGE QLHVKISDLGLSREIYSADYYRVQS KSLLPIRWMPPEAIMYGKFSSDSDI WSFGVVLWEIFSFGLQPYYGFSNQE VIEMVRKRQLLPCSEDCPPRMYSLM TECWNEIPSRRPRFKDIHVRLRSWE GLSSHTSSTTPSGGNATTQTTSLSA SPVSNLSNPRYPNYMFPSQGITPQG QIAGFIGPPIPQNQRFIPINGYPIP PGYAAFPAAHYQPTGPPRVIQHCPP PKSRSPSSASGSTSTGHVTSLPSSG SNQEANIPLLPHMSIPNHPGGMGIT VFGNKSQKPYKIDSKQASLLGDANI HGHTESMISAEL |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
