Recombinant Human S100 Calcium Binding Protein B, His-tagged

• Cat.No.: S100B-2724H
• Product Overview: Recombinant human S100B protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography techniques. MW = 12.8 kDa (112aa), confirmed by MALDI-TOF.

Specification

• Cat. No.: S100B-2724H
• Description: S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. This protein function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly.
• Source: E.coli.
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEVVDKVMET LDNDGDGECD FQEFMAFVAM VTTACHEFFE HE
• Form: Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 1mM DTT, 10% glycerol.
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: S100B S100 calcium binding protein B [ Homo sapiens ]
• Synonyms: S100B; S100 calcium binding protein B; NEF; S100; S100 calcium-binding protein, beta; S100 beta; OTTHUMP00000174958; S-100 calcium-binding protein, beta chain; S100 calcium binding protein, beta (neural); S100 calcium-binding protein, beta (neural); Protein S100-B; S100 calcium-binding protein B; S-100 protein subunit beta; S-100 protein beta chain
• Gene ID: 6285
• mRNA Refseq: NM_006272
• Protein Refseq: NP_006263
• MIM: 176990
• UniProt ID: P04271
• Chromosome Location: 21q22.3
• Function: S100 beta binding; calcium ion binding; calcium-dependent protein binding; protein homodimerization activity; protein homodimerization activity; tau protein binding; zinc ion binding

Reviews

03/15/2022

One major advantage of S100B protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.

09/29/2019

The S100B protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

10/23/2018

The manufacturer of S100B protein plays a crucial role in supporting my research efforts.

Q&As

How does S100B help in the diagnosis of traumatic brain injury (TBI)?

Elevated S100B levels in the blood can indicate TBI, and its measurement can aid in TBI diagnosis and severity assessment.

What conditions can S100B be used to diagnose?

S100B can be used to diagnose brain injuries, such as traumatic brain injury and stroke.

How is S100B measured in clinical settings?

S100B levels are typically measured through a blood test.

What precautions should be taken when interpreting S100B results?

Results should be interpreted in the context of the patient's clinical history and other diagnostic tests.

How is S100B used in the context of neurodegenerative diseases?

S100B may help in monitoring disease progression and severity in conditions like Alzheimer's disease.