Recombinant Human S100A8 & S100A9 protein, His-tagged

• Cat.No.: S100A8 & S100A9-2218H
• Product Overview: Recombinant Human S100A8 & S100A9(P05109/P06702)(Met1-Glu93/Thr2-Pro114) peotein is expressed from E. coli with a His Tag at the C-terminal.

Specification

• Source: E.coli
• Species: Human
• Tag: His
• Form: Supplied as 0.22um filtered solution in in 2mM DTT, PBS, pH 7.2.
• Molecular Mass: The protein has a predicted MW of 11.7/13.2 kDa. Due to glycosylation, the protein migrates to 12/14 kDa based on Bis-Tis PAGE result.
• Protein length: Met1-Glu93/Thr2-Pro114
• Endotoxin: Less than 1 EU per ug by the LAL method.
• Purity: >95% as determined by Tris-Bis PAGE; >95% as determined by HPLC.
• Notes: For research use only. Not for use in clinical diagnostic procedures.
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: S100A8 S100 calcium binding protein A8
• Official Symbol: S100A8
• Gene ID: 6279
• mRNA Refseq: NM_002964
• Protein Refseq: NP_002955
• MIM: 123885
• UniProt ID: P05109

Reviews

02/01/2022

Dependable protein quantification, ensures experimental accuracy.

10/29/2020

Consistent western blot results, a lab essential.

03/12/2020

Expert protein engineering support, essential for our projects.

Q&As

How do alterations in S100A8 expression impact cellular stress responses and aging?

Changes in S100A8 expression impact cellular stress responses, with implications for aging and age-related diseases.

How does S100A8 contribute to the pathogenesis of cancer, especially in terms of tumor growth and metastasis?

S100A8 contributes to cancer development, influencing tumor cell proliferation and metastatic potential.

What is the impact of S100A8 on wound healing and tissue repair mechanisms?

S100A8 is involved in wound healing, affecting tissue repair and regeneration.

How does S100A8 interact with calcium ions and what are the implications for inflammatory processes?

S100A8 binds calcium ions, modulating inflammatory processes and cytokine production.

How does S100A8 influence the development and progression of cardiovascular diseases?

S100A8 affects cardiovascular disease development, impacting inflammation and vascular integrity.

What role does S100A8 play in the immune response, particularly in autoimmune diseases?

S100A8 plays a significant role in the immune response, impacting the pathogenesis of autoimmune diseases.

What are the effects of S100A8 on skin homeostasis and the development of skin disorders?

S100A8 influences skin health, playing a role in maintaining skin barrier function and in skin disorders.