| Description : |
The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Fc |
| Form : |
Lyophilized |
| Molecular Mass : |
72.5 kDa |
| Protein Length : |
478 |
| AA Sequence : |
MGRCCFYTAGTLSLLLLVTSVTLLV ARVFQKAVDQSIEKKIVLRNGTEAF DSWEKPPLPVYTQFYFFNVTNPEEI LRGETPRVEEVGPYTYRELRNKANI QFGDNGTTISAVSNKAYVFERDQSV GDPKIDLIRTLNIPVLTVIEWSQVH FLREIIEAMLKAYQQKLFVTHTVDE LLWGYKDEILSLIHVFRPDISPYFG LFYEKNGTNDGDYVFLTGEDSYLNF TKIVEWNGKTSLDWWITDKCNMING TDGDSFHPLITKDEVLYVFPSDFCR SVYITFSDYESVQGLPAFRYKVPAE ILANTSDNAGFCIPEGNCLGSGVLN VSICKNGAPIIMSFPHFYQADERFV SAIEGMHPNQEDHETFVDINPLTGI ILKAAKRFQINIYVKKLDDFVETGD IRTMVFPVMYLNESVHIDKETASRL KSMINTTLIITNIPYIIMALGVFFG LVFTWLACKGQGSMDEGTADERAPL IRT |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
