Recombinant Human FLT1 Protein

• Cat.No.: Sflt1-0109H
• Product Overview: Recombinant Human Soluble fms-like Tyrosine Kinase-1 (Sflt-1) Protein is produced by Mammalian expression system and the target gene encoding Met1-Glu758 is expressed. The Sflt-1 protein has a calculated molecular mass of 85.5 kDa and migrates as an 110-120 kDa band in SDS-PAGE under reducing conditions due to glycosylation.

Specification

• Species: Human
• Source: HEK293
• Protein Length: 1-758 aa
• Description: This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
• Molecular Mass: 85.5 kDa
• Application: Immunogen, calibrator, standard or other applications
• Purity: ≥90% as determined by reducing SDS-PAGE
• Storage: Short term (up to 7 days) store at 2–8 centigrade. Long term, store at 20 centigrade. Avoid multiple freeze/thaw cycles.
• Storage Buffer: Supplied as a 0.2 μm filtered solution of PBS, pH7.4
• Shipping: The product is shipped on ice pack. Upon receipt, store it immediately at -20 centigrade or lower.

Gene Information

• Gene Name: FLT1 fms related receptor tyrosine kinase 1 [ Homo sapiens (human) ]
• Official Symbol: FLT1
• Synonyms: FLT1; fms related receptor tyrosine kinase 1; FLT; FLT-1; VEGFR1; VEGFR-1; vascular endothelial growth factor receptor 1 fms related tyrosine kinase 1 fms-like tyrosine kinase 1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) tyrosine-protein kinase FRT tyrosine-protein kinase receptor FLT vascular permeability factor receptor EC 2.7.10.1
• Gene ID: 2321
• mRNA Refseq: NM_002019
• Protein Refseq: NP_002010
• MIM: 165070
• UniProt ID: P17948