Active Recombinant Human SFRP5 Protein, HA-tagged
Cat.No. : | SFRP5-2621H |
Product Overview : | Recombinant Human SFRP5 Protein (Glu30-His317) with an N-terminal HA (YPYDVPDYA) tag was expressed in Chinese Hamster Ovary cell line. |
- Specification
- Gene Information
- Related Products
Description : | Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. |
Source : | CHO |
Species : | Human |
Tag : | HA |
Predicted N Terminal : | Tyr (HA), Trp37 & Ser46 |
Bio-activity : | Measured by its ability to inhibit Topflash reporter activity in HEK293T human embryonic kidney cells. The ED50 for this effect is 0.25-1 μg/mL in the presence of 100 ng/mL Recombinant Mouse Wnt‑3a. |
Molecular Mass : | 30-40 kDa, reducing conditions |
Endotoxin : | <0.10 EU per 1 μg of the protein by the LAL method. |
Purity : | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain |
Storage : | Avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS and NaCl. |
Reconstitution : | Reconstitute at 100 μg/mL in PBS. |
Gene Name : | SFRP5 secreted frizzled related protein 5 [ Homo sapiens (human) ] |
Official Symbol : | SFRP5 |
Synonyms : | SFRP5; secreted frizzled related protein 5; SARP3; secreted frizzled-related protein 5; FRP-1b; SARP-3; frizzled-related protein 1b; sFRP-5; secreted apoptosis related protein 3 |
Gene ID : | 6425 |
mRNA Refseq : | NM_003015 |
Protein Refseq : | NP_003006 |
MIM : | 604158 |
UniProt ID : | Q5T4F7 |
Products Types
◆ Recombinant Protein | ||
SFRP5-8086M | Recombinant Mouse SFRP5 Protein, His (Fc)-Avi-tagged | +Inquiry |
SFRP5-1226H | Recombinant Human SFRP5 Protein, His&SUMO-tagged | +Inquiry |
Sfrp5-8103R | Recombinant Rat Sfrp5 protein, His-tagged | +Inquiry |
Sfrp5-3487M | Recombinant Mouse Sfrp5 protein, His-tagged | +Inquiry |
SFRP5-9363Z | Recombinant Zebrafish SFRP5 | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionSFRP5 expression is regulated by various factors, including transcriptional regulators and microRNAs. Tissue-specific expression is influenced by developmental cues and environmental signals.
SFRP5 has a cysteine-rich domain that interacts with Wnt ligands, preventing their binding to Frizzled receptors. The structural configuration is crucial for modulating Wnt signaling.
Genetic variations in the SFRP5 gene have been identified, and certain polymorphisms are associated with altered susceptibility to diseases such as cancer and metabolic disorders.
SFRP5 plays a role in tissue regeneration by modulating Wnt signaling during repair processes. Understanding its function contributes to the development of regenerative medicine strategies.
Altered SFRP5 expression is associated with various diseases, including cancer and metabolic disorders, where dysregulated Wnt signaling plays a role in disease progression.
Customer Reviews (3)
Write a reviewSatisfied customer—great product!
Impressed with the quality control. This product is a gem in our lab experiments.
Outstanding lab product!
Ask a Question for All SFRP5 Products
Required fields are marked with *
My Review for All SFRP5 Products
Required fields are marked with *
Inquiry Basket