Recombinant Human SGO1 Protein, Myc/DDK-tagged, C13 and N15-labeled
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Cat.No. : | SGO1-6096H |
Product Overview : | SGOL1 MS Standard C13 and N15-labeled recombinant protein (NP_001012411) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
Description : | The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. |
Source : | HEK293 |
Species : | Human |
Tag : | Myc/DDK |
Molecular Mass : | 31.1 kDa |
AA Sequence : | MAKERCLKKS FQDSLEDIKK RMKEKRNKNL AEIGKRRSFI AAPCQIITNT STLLKNYQDN NKMLVLALEN EKSKVKEAQD IILQLRKECY YLTCQLYALK GKLTSQQTVE PAQNQEICSS GMDPNSDDSS RNLFVKDLPQ IPLEETELPG QGESFQIEDQ IPTIPQDTLG VDFDSATPPE TQQSPHLSLK DITNVSLYPV VKIRRLSLSP KKNKASPAVA LPKRRCTASV NYKEPTLASK LRRGDPFTDL CFLNSPIFKQ KKDLRRSKKS MKQIQTRTRP LEQKLISEED LAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
SDS-PAGE : |
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Gene Name : | SGO1 shugoshin 1 [ Homo sapiens (human) ] |
Official Symbol : | SGO1 |
Synonyms : | SGO1; shugoshin 1; SGO; CAID; SGOL1; NY-BR-85; shugoshin 1; serologically defined breast cancer antigen NY-BR-85; shugoshin 1AB protein; shugoshin 1CD protein; shugoshin 1EF protein; shugoshin 1GH protein; shugoshin 1KL protein |
Gene ID : | 151648 |
mRNA Refseq : | NM_001012411 |
Protein Refseq : | NP_001012411 |
MIM : | 609168 |
UniProt ID : | Q5FBB7 |
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