| Description : |
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
63.3 kDa |
| AA Sequence : |
MPSTDLLMLKAFEPYLEILEVYSTK AKNYVNGHCTKYEPWQLIAWSVVWT LLIVWGYEFVFQPESLWSRFKKKCF KLTRKMPIIGRKIQDKLNKTKDDIS KNMSFLKVDKEYVKALPSQGLSSSA VLEKLKEYSSMDAFWQEGRASGTVY SGEEKLTELLVKAYGDFAWSNPLHP DIFPGLRKIEAEIVRIACSLFNGGP DSCGCVTSGGTESILMACKAYRDLA FEKGIKTPEIVAPQSAHAAFNKAAS YFGMKIVRVPLTKMMEVDVRAMRRA ISRNTAMLVCSTPQFPHGVIDPVPE VAKLAVKYKIPLHVDACLGGFLIVF MEKAGYPLEHPFDFRVKGVTSISAD THKYGYAPKGSSLVLYSDKKYRNYQ FFVDTDWQGGIYASPTIAGSRPGGI SAACWAALMHFGENGYVEATKQIIK TARFLKSELENIKGIFVFGNPQLSV IALGSRDFDIYRLSNLMTAKGWNLN QLQFPPSIHFCITLLHARKRVAIQF LKDIRESVTQIMKNPKAKTTGMGAI YGMAQTTVDRNMVAELSSVFLDSLY STDTVTQGSQMNGSPKPHTRTRPLE QKLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
