"SGSH" Related Products


Recombinant Human SGSH protein, His-tagged

Cat.No.: SGSH-195H
Product Overview: Recombinant Human SGSH fused with His tag at C-terminal was expressed in HEK293.
Description: This gene encodes one of several enzymes involved in the lysosomal degradation of heparan sulfate. Mutations in this gene are associated with Sanfilippo syndrome A, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. Transcripts of varying sizes have been reported but their biological validity has not been determined.
Source: HEK293
Species: Human
Tag: His
Form: Supplied as a 0.2 µM filtered solution of 20mM TrisHCl,150mM NaCl,1mM GaCl2,10%Glycerol,pH7.5
Molecular Mass: 55.72kD
Endotoxin: Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
Gene Name: SGSH N-sulfoglucosamine sulfohydrolase [ Homo sapiens ]
Official Symbol: SGSH
Synonyms: SGSH; N-sulfoglucosamine sulfohydrolase; N-sulphoglucosamine sulphohydrolase; HSS; MPS3A; mucopolysaccharidosis type IIIA; SFMD; sulfamidase; sulphamidase; heparan sulfate sulfatase; sulfoglucosamine sulfamidase;
Gene ID: 6448
mRNA Refseq: NM_000199
Protein Refseq: NP_000190
MIM: 605270
UniProt ID: P51688
Chromosome Location: 17q25.3
Pathway: Glycosaminoglycan degradation, organism-specific biosystem; Glycosaminoglycan degradation, conserved biosystem; Heparan sulfate degradation, organism-specific biosystem; Heparan sulfate degradation, conserved biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function: N-sulfoglucosamine sulfohydrolase activity; catalytic activity; hydrolase activity; metal ion binding; sulfuric ester hydrolase activity;

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