| Description : |
This gene encodes a member of the Rho GTPase activating protein (RhoGAP) family. The encoded protein regulates Rac signaling and plays a role in cytoskeletal dynamics, cell motility and epithelial junction formation. This protein's association with the exocyst complex, which tethers secretory vesicles to the plasma membrane, has been demonstrated to be important in cell motility. In a distinct complex, this protein has been shown to regulate epithelial junction formation and morphogenesis. By interacting with the Plexin-D1 cell surface receptor, this protein mediates changes in the cytoskeleton in response to semaphorin binding. This protein may promote metastasis in human liver cancer cells and tissues. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
75.5 kDa |
| AA Sequence : |
MMKRQLHRMRQLAQTGSLGRTPETA EFLGEDLLQVEQRLEPAKRAAHNIH KRLQACLQGQSGADMDKRVKKLPLM ALSTTMAESFKELDPDSSMGKALEM SCAIQNQLARILAEFEMTLERDVLQ PLSRLSEEELPAILKHKKSLQKLVS DWNTLKSRLSQATKNSGSSQGLGGS PGSHSHTTMANKVETLKEEEEELKR KVEQCRDEYLADLYHFVTKEDSYAN YFIRLLEIQADYHRRSLSSLDTALA ELRENHGQADHSPSMTATHFPRVYG VSLATHLQELGREIALPIEACVMML LSEGMKEEGLFRLAAGASVLKRLKQ TMASDPHSLEEFCSDPHAVAGALKS YLRELPEPLMTFDLYDDWMRAASLK EPGARLQALQEVCSRLPPENLSNLR YLMKFLARLAEEQEVNKMTPSNIAI VLGPNLLWPPEKEGDQAQLDAASVS SIQVVGVVEALIQSADTLFPGDINF NVSGLFSAVTLQDTVSDRLASEELP STAVPTPATTPAPAPAPAPAPAPAL ASAATKERTESEVPPRPASPKVTRS PPETAAPVEDMARRTKRPAPARPTM PPPQVSGSRSSPPAPPLPPGSGSPG TPQALPRRLVGSSLRAPTVPPPLPP TPPQPARRQSRRSPASPSPASPGPA SPSPVSLSNPAQVDLGAATAEGGAP EAISGVPTPPAIPPQPRPRSLASET NTRTRPLEQKLISEEDLAANDILDY KDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
