| Description : |
This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
101.4 kDa |
| AA Sequence : |
MPPRRSIVEVKVLDVQKRRVPNKHY VYIIRVTWSSGSTEAIYRRYSKFFD LQMQMLDKFPMEGGQKDPKQRIIPF LPGKILFRRSHIRDVAVKRLIPIDE YCKALIQLPPYISQCDEVLQFFETR PEDLNPPKEEHIGKKKSGGDQTSVD PMVLEQYVVVANYQKQESSEISLSV GQVVDIIEKNESGWWFVSTAEEQGW VPATCLEGQDGVQDEFSLQPEEEEK YTVIYPYTARDQDEMNLERGAVVEV IQKNLEGWWKIRYQGKEGWAPASYL KKNSGEPLPPKPGPGSPSHPGALDL DGVSRQQNAVGREKELLSSQRDGRF EGRPVPDGDAKQRSPKMRQRPPPRR DMTIPRGLNLPKPPIPPQVEEEYYT IAEFQTTIPDGISFQAGLKVEVIEK NLSGWWYIQIEDKEGWAPATFIDKY KKTSNASRPNFLAPLPHEVTQLRLG EAAALENNTGSEATGPSRPLPDAPH GVMDSGLPWSKDWKGSKDVLRKASS DMSASAGYEEISDPDMEEKPSLPPR KESIIKSEGELLERERERQRTEQLR GPTPKPPGVILPMMPAKHIPPARDS RRPEPKPDKSRLFQLKNDMGLECGH KVLAKEVKKPNLRPISKSKTDLPEE KPDATPQNPFLKSRPQVRPKPAPSP KTEPPQGEDQVDICNLRSKLRPAKS QDKSLLDGEGPQAVGGQDVAFSRSF LPGEGPGRAQDRTGKQDGLSPKEIS CRAPPRPAKTTDPVSKSVPVPLQEA PQQRPVVPPRRPPPPKKTSSSSRPL PEVRGPQCEGHESRAAPTPGRALLV PPKAKPFLSNSLGGQDDTRGKGSLG PWGTGKIGENREKAAAASVPNADGL KDSLYVAVADFEGDKDTSSFQEGTV FEVREKNSSGWWFCQVLSGAPSWEG WIPSNYLRKKPSGPTRTRRLEQKLI SEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
