Recombinant Human SHOX2

• Cat.No.: SHOX2-31358TH
• Product Overview: Recombinant fragment corresponding to amino acids 117-204 of Human SHOX2 with proprietary tag; Predicted MWt 35.31 kDa.

Specification

• Description: This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants.
• Protein length: 88 amino acids
• Molecular Weight: 35.310kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.31% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: SPELKDRKDDAKGMEDEGQTKIKQR RSRTNFTLEQLNELERLFDETHYPD AFMREELSQRLGLSEARVQVWFQNR RAKCRKQENQLHK
• Sequence Similarities: Belongs to the paired homeobox family. Bicoid subfamily.Contains 1 homeobox DNA-binding domain.

Gene Information

• Gene Name: SHOX2 short stature homeobox 2 [ Homo sapiens ]
• Official Symbol: SHOX2
• Synonyms: SHOX2; short stature homeobox 2; short stature homeobox protein 2; OG12; OG12X; SHOT
• Gene ID: 6474
• mRNA Refseq: NM_001163678
• Protein Refseq: NP_001157150
• MIM: 602504
• Uniprot ID: O60902
• Chromosome Location: 3q25.32
• Function: transcription regulatory region sequence-specific DNA binding