Recombinant Human SIGLEC10 protein, His-tagged

• Cat.No.: SIGLEC10-059H
• Product Overview: Human Siglec-2/CD22 is expressed from mammalian with a His tag and Avi Tag at the C-terminal. It contains Asp20-Arg687.

Specification

• Description: Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Supplied as 0.22um filtered solution in 20mM PB, 150mM Nal, 25mM Arginine(pH 7.4).
• Molecular Mass: The protein has a predicted MW of 78.1 kDa. Due to glycosylation, the protein migrates to 100- 115KDa based on Bis-Tris PAGE result.
• Protein length: It contains Asp20-Arg687.
• Endotoxin: Less than 0.05EU per ug by the LAL method.
• Purity: > 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: SIGLEC10 sialic acid binding Ig-like lectin 10 [ Homo sapiens ]
• Official Symbol: SIGLEC10
• Synonyms: siglec 10; siglec-10; siglec10; Sialic acid-binding Ig-like lectin 10; Siglec-like protein 2; SLG2
• Gene ID: 89790
• mRNA Refseq: NM_001171156
• Protein Refseq: NP_001164627
• MIM: 606091
• UniProt ID: Q96LC7