Species : |
Human |
Source : |
HEK293 |
Tag : |
His |
Protein Length : |
It contains Asp20-Arg687. |
Description : |
Siglec-10 is a ligand for CD52, the target of the therapeutic monoclonal antibody Alemtuzumab. It is also reported to bind to Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule CD24 also known as HSA (Heat-stable antigen).Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system. |
Form : |
Supplied as 0.22um filtered solution in 20mM PB, 150mM Nal, 25mM Arginine(pH 7.4). |
Molecular Mass : |
The protein has a predicted MW of 78.1 kDa. Due to glycosylation, the protein migrates to 100- 115KDa based on Bis-Tris PAGE result. |
Endotoxin : |
Less than 0.05EU per ug by the LAL method. |
Purity : |
> 95% as determined by Bis-Tris PAGE; > 95% as determined by HPLC |
Storage : |
The product should be stored at -70°C. Please do not repeated freeze-thaw cycles. |
Reconstitution : |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |