Recombinant Human SIGLEC10 protein, Mouse IgG2a Fc-tagged, low endotoxin SIGLEC10-331H

Recombinant Human SIGLEC10 protein, Mouse IgG2a Fc-tagged, low endotoxin

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Recombinant Human SIGLEC10 protein, Mouse IgG2a Fc-tagged, low endotoxin

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Cat.No. : SIGLEC10-331H
Product Overview : Recombinant Human SIGLEC10 protein (Met17-Thr546)(low endotoxin), fused to Mouse IgG2a Fc tag at C-terminus, was expressed in human 293 cells (HEK293).
Description : The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
Source : HEK293
Species : Human
Tag : Mouse IgG2a Fc
Form : Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 85.6 kDa. The protein migrates as 90-120 KDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 530
Endotoxin : Less than 0.1 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
SDS-PAGE of SIGLEC10-331H :

Human Siglec-10, Mouse IgG2a Fc Tag, low endotoxin on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.

Bioactivity-ELISA of SIGLEC10-331H :

Immobilized Human Siglec-10, Mouse IgG2a Fc Tag, low endotoxin at 5 μg/mL (100 μL/well) can bind Anti-Human Siglec-10 MAb, human IgG with a linear range of 0.6-20 ng/mL (QC tested).

Gene Name : SIGLEC10
Official Symbol : SIGLEC10
Synonyms : SIGLEC10; sialic acid binding Ig-like lectin 10; sialic acid-binding Ig-like lectin 10; MGC126774; PRO940; sialic acid binding Ig like lectin 10 Ig like lectin 7; SIGLEC 10; siglec like gene 2; SLG2; siglec-like gene 2; siglec-like protein 2; sialic acid binding Ig-like lectin 10 Ig-like lectin 7; SIGLEC-10
Gene ID : 89790
mRNA Refseq : NM_001171156
Protein Refseq : NP_001164627
MIM : 606091
UniProt ID : Q96LC7

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