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Recombinant Human SIRP alphaV2 protein, His-Avi-tagged, Biotinylated

Cat.No. : SIRP alphaV2-864HB
Product Overview : Biotinylated Human SIRP alphaV2, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Arg 369 (Accession # ATD50864.1).
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Description : Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Source : HEK293
Species : Human
Tag : His-Avi
Predicted N Terminal : Glu 31
Form : Please contact us for detailed information.
Molecular Mass : The protein has a calculated MW of 40.7 kDa.
Protein length : Glu 31 - Arg 369
Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Synonyms : SHPS1; SIRPA; CD172A; BIT; MFR; MYD1; P84; PTPNS1
Synonyms : SHPS1; SIRPA; CD172A; BIT; MFR; MYD1; P84; PTPNS1

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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