Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human SIRT2 protein, T7/His-tagged

Cat.No. : SIRT2-174H
Product Overview : Recombinant human SIRT2 cDNA (389aa, isoform-2) protein fused with T7-His-TEV cleavage site Tag at N-terminal was expressed in E. coli.
  • Specification
  • Gene Information
  • Related Products
Source : E. coli
Species : Human
Tag : T7/His
Form : 0.5 mg/ml, sterile-filtered, in 20 mM pH 8.0 Tris-HCl Buffer, with proprietary formulation of NaCl, KCl, EDTA, arginine, DTT and Glycerol.
AA Sequence : MASMTGGQQMGRGHHHHHHGNLYFQ GGEFDFLRNLFSQTLSLGSQKERLL DELTLEGVARYMQSERCRRVICLVG AGISTSAGIPDFRSPSTGLYDNLEK YHLPYPEAIFEISYFKKHPEPFFAL AKELYPGQFKPTICHYFMRLLKDKG LLLRCYTQNIDTLERIAGLEQEDLV EAHGTFYTSHCVSASCRHEYPLSWM KEKIFSEVTPKCEDCQSLVKPDIVF FGESLPARFFSCMQSDFLKVDLLLV MGTSLQVQPFASLISKAPLSTPRLL INKEKAGQSDPFLGMIMGLGGGMDF DSKKAYRDVAWLGECDQGCLALAEL LGWKKELEDLVRREHASIDAQSGAG VPNPSTSASPKKSPPPAKDEARTTE REKPQ
Purity : >90% by SDS-PAGE.
Storage : Keep at -80°C for long term storage. Product is stable at 4 °C for at least 30 days.
Gene Name : SIRT2 sirtuin 2 [ Homo sapiens ]
Official Symbol : SIRT2
Synonyms : SIRT2; sirtuin 2; NAD-dependent deacetylase sirtuin-2; sirtuin type 2; SIR2-like protein 2; SIR2; SIR2L; SIR2L2; FLJ35621; FLJ37491;
Gene ID : 22933
mRNA Refseq : NM_030593
Protein Refseq : NP_085096
MIM : 604480
UniProt ID : Q8IXJ6
Chromosome Location : 19q13
Pathway : Signaling events mediated by HDAC Class I, organism-specific biosystem; Signaling events mediated by HDAC Class III, organism-specific biosystem;
Function : NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; histone acetyltransferase binding; histone deacetylase binding; hydrolase activity; metal ion binding; protein binding; protein deacetylase activity; transcription factor binding; tubulin deacetylase activity; ubiquitin binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does SIRT2 participate in the regulation of cellular stress responses? 02/09/2022

SIRT2 is involved in stress response pathways, deacetylating and modulating the activity of stress-responsive proteins, contributing to cellular adaptation to various stress conditions.

How does SIRT2 contribute to the regulation of cellular metabolism? 07/15/2021

SIRT2 influences cellular metabolism by deacetylating enzymes involved in glycolysis, fatty acid metabolism, and mitochondrial function, impacting overall energy homeostasis.

Explain the molecular mechanisms underlying SIRT2-mediated deacetylation of target proteins. 11/30/2020

SIRT2 uses NAD+ as a cofactor to remove acetyl groups from lysine residues, a process that links cellular metabolic state to protein acetylation and deacetylation.

Discuss the role of SIRT2 in the regulation of cell cycle progression. 08/19/2019

SIRT2 influences cell cycle progression by deacetylating key regulators, such as cyclin-dependent kinases (CDKs) and checkpoint proteins, impacting cell cycle checkpoints and progression.

Discuss the role of SIRT2 in neurodegenerative diseases and its potential as a therapeutic target. 01/04/2018

SIRT2 has been implicated in neurodegenerative diseases, and modulating its activity is explored as a potential therapeutic strategy for conditions such as Parkinson's disease.

Customer Reviews (3)

Write a review
Reviews
04/15/2021

    Efficient and knowledgeable customer service—made our purchase straightforward.

    11/02/2020

      This recombined protein is our go-to for dependable and accurate results.

      08/30/2018

        Punctual delivery is crucial, and this product arrived right on time.

        Ask a Question for All SIRT2 Products

        Required fields are marked with *

        My Review for All SIRT2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends