| Description : |
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
70.1 kDa |
| AA Sequence : |
METTPLNSQKQLSACEDGEDCQENG VLQKVVPTPGDKVESGQISNGYSAV PSPGAGDDTRHSIPATTTTLVAELH QGERETWGKKVDFLLSVIGYAVDLG NVWRFPYICYQNGGGAFLLPYTIMA IFGGIPLFYMELALGQYHRNGCISI WRKICPIFKGIGYAICIIAFYIASY YNTIMAWALYYLISSFTDQLPWTSC KNSWNTGNCTNYFSEDNITWTLHST SPAEEFYTRHVLQIHRSKGLQDLGG ISWQLALCIMLIFTVIYFSIWKGVK TSGKVVWVTATFPYIILSVLLVRGA TLPGAWRGVLFYLKPNWQKLLETGV WIDAAAQIFFSLGPGFGVLLAFASY NKFNNNCYQDALVTSVVNCMTSFVS GFVIFTVLGYMAEMRNEDVSEVAKD AGPSLLFITYAEAIANMPASTFFAI IFFLMLITLGLDSTFAGLEGVITAV LDEFPHVWAKRRERFVLAVVITCFF GSLVTLTFGGAYVVKLLEEYATGPA VLTVALIEAVAVSWFYGITQFCRDV KEMLGFSPGWFWRICWVAISPLFLL FIICSFLMSPPQLRLFQYNYPYWSI ILGYCIGTSSFICIPTYIAYRLIIT PGTFKERIIKSITPETPTEIPCGDI RLNAVTRTRPLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
