Recombinant Human SMOX Protein, Myc/DDK-tagged, C13 and N15-labeled

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Recombinant Human SMOX Protein, Myc/DDK-tagged, C13 and N15-labeled

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Cat.No. : SMOX-6015H
Product Overview : SMOX MS Standard C13 and N15-labeled recombinant protein (NP_787034) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
Description : Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 56.1 kDa
AA Sequence : MQSCESSGDS ADDPLSRGLR RRGQPRVVVI GAGLAGLAAA KALLEQGFTD VTVLEASSHI GGRVQSVKLG HATFELGATW IHGSHGNPIY HLAEANGLLE ETTDGERSVG RISLYSKNGV ACYLTNHGRR IPKDVVEEFS DLYNEVYNLT QEFFRHDKPV NAESQNSVGV FTREEVRNRI RNDPDDPEAT KRLKLAMIQQ YLKVESCESS SHSMDEVSLS AFGEWTEIPG AHHIIPSGFM RVVELLAEGI PAHVIQLGKP VRCIHWDQAS ARPRGPEIEP RGVLKRQYTS FFRPGLPTEK VAAIHRLGIG TTDKIFLEFE EPFWGPECNS LQFVWEDEAE SHTLTYPPEL WYRKICGFDV LYPPERYGHV LSGWICGEEA LVMEKCDDEA VAEICTEMLR QFTGNPNIPK PRRILRSAWG SNPYFRGSYS YTQVGSSGAD VEKLAKPLPY TESSKTAPMQ VLFSGEATHR KYYSTTHGAL LSGQREAARL IEMYRDLFQQ GTTRTRPLEQ KLISEEDLAA NDILDYKDDD DKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE :

Gene Name : SMOX spermine oxidase [ Homo sapiens (human) ]
Official Symbol : SMOX
Synonyms : SMOX; spermine oxidase; PAO; SMO; PAO1; PAOH; PAO-1; PAOH1; C20orf16l; spermine oxidase; flavin containing amine oxidase; flavin-containing spermine oxidase; polyamine oxidase 1; putative cyclin G1 interacting protein; EC 1.5.3.16
Gene ID : 54498
mRNA Refseq : NM_175840
Protein Refseq : NP_787034
MIM : 615854
UniProt ID : Q9NWM0

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