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Recombinant Human SNAP23 protein, His & T7-tagged

Cat.No. : SNAP23-8116H
Product Overview : Recombinant Human SNAP23 aa. (Met1~Ser211 (Accession # O00161)) fused with N-terminal His & T7 tag was produced in E. coli cells.
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  • Gene Information
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Description : Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene.
Source : E. coli
Species : Human
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 27.1kDa
Protein length : Met1~Ser211 (Accession # O00161)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >90%
Characteristic : The isoelectric point is 4.9.
Applications : SDS-PAGE; WB; ELISA; IP
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : SNAP23 synaptosome associated protein 23 [ Homo sapiens (human) ]
Official Symbol : SNAP23
Synonyms : SNAP-23; SNAP23A; SNAP23B; HsT17016; synaptosomal-associated protein, 23kD; synaptosomal-associated protein, 23kDa; synaptosome associated protein 23kDa; vesicle-membrane fusion protein SNAP-23; synaptosomal-associated protein 23
Gene ID : 8773
mRNA Refseq : NM_003825.3
Protein Refseq : NP_003816.2
UniProt ID : O00161

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How does SNAP23 expression change in neurodegenerative diseases? 10/02/2022

In neurodegenerative diseases such as Alzheimer's disease, the expression level of SNAP23 may be reduced, which may affect the release of neurotransmitters and nerve signaling.

Does SNAP23 affect neuronal death? 04/19/2022

SNAP23 may influence neuronal death by regulating the fusion of synaptic vesicles and the release of neurotransmitters. Studies have shown that reducing the expression level of SNAP23 may increase the risk of neuronal death.

How does SNAP23 relate to neuroinflammation? 02/08/2022

Recent studies have found that SNAP23 is associated with neuroinflammation. The level of expression of SNAP23 may affect the intensity and extent of the inflammatory response.

How are the interactions between SNAP23 and other proteins regulated? 11/16/2021

The interaction between SNAP23 and other proteins is regulated by the formation of complexes or the modulation of signal transduction pathways. These interactions can be influenced by a variety of factors, such as ion concentrations, neurotransmitters, and growth factors.

What are the key findings from the SNAP23 study? 11/03/2021

Recent studies have found that SNAP23 plays an important role in neurodegenerative diseases such as Alzheimer's disease. The study also found that SNAP23 expression levels were associated with neuroinflammation and neuronal death.

What are the other roles of SNAP23 in the nervous system? 01/14/2020

In addition to being involved in nerve signaling and neuronal death, SNAP23 may have effects on the nervous system in other ways. For example, SNAP23 may be involved in processes such as synaptic plasticity and learning and memory.

Customer Reviews (3)

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Reviews
07/29/2022

    The pharmacodynamic parameters of SNAP23 were better.

    04/23/2021

      SNAP23 has a strong desensitization potential to specific allergens.

      03/16/2021

        SNAP23 has good compatibility and stability with various excipients.

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