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Recombinant Human SNCA protein, His-tagged

Cat.No. : SNCA-166H
Product Overview : Recombinant Human TACSTD2 protein (Met1-Ala140) was fused to His-tag at the C-terminus and expressed in E.coli.
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Description : Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Source : E.coli
Species : Human
Tag : His
Predicted N Terminal : Met1
Form : Lyophilized from 0.22 μm filtered solution in 100 mM NaAC, pH7.0, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 16.3 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE).
Protein length : Met1-Ala140
Endotoxin : Less than 1.0 EU per μg by the LAL method.
Purity : >90% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : SNCA
Official Symbol : SNCA
Synonyms : PD1; NACP; PARK1; PARK4
Gene ID : 6622
mRNA Refseq : NM_000345.4
Protein Refseq : NP_000336.1
MIM : 163890
UniProt ID : P37840

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can SNCA protein levels in cerebrospinal fluid be used as a diagnostic marker for Parkinson's disease? 10/11/2022

Yes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.

What potential therapeutic strategies target SNCA protein for Parkinson's disease treatment? 03/27/2022

Therapies may include reducing SNCA aggregation or preventing its misfolding.

Are there any genetic mutations related to SNCA protein that increase the risk of Parkinson's disease? 10/17/2018

Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.

How is SNCA protein associated with neurodegenerative diseases? 06/11/2016

Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.

Are there any ongoing clinical trials investigating SNCA-related therapies? 05/27/2016

Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.

Customer Reviews (3)

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Reviews
08/31/2020

    Its integrity and reliability make it an ideal choice to address the specific objectives of my research.

    03/12/2020

      Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.

      10/16/2017

        In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.

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