Recombinant Human SNCA protein, His-tagged
Cat.No. : | SNCA-166H |
Product Overview : | Recombinant Human TACSTD2 protein (Met1-Ala140) was fused to His-tag at the C-terminus and expressed in E.coli. |
- Specification
- Gene Information
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Description : | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Met1 |
Form : | Lyophilized from 0.22 μm filtered solution in 100 mM NaAC, pH7.0, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 16.3 kDa. The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE). |
Protein length : | Met1-Ala140 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >90% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20°C or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | SNCA |
Official Symbol : | SNCA |
Synonyms : | PD1; NACP; PARK1; PARK4 |
Gene ID : | 6622 |
mRNA Refseq : | NM_000345.4 |
Protein Refseq : | NP_000336.1 |
MIM : | 163890 |
UniProt ID : | P37840 |
Products Types
◆ Recombinant Protein | ||
SNCA-02H | Recombinant Human SNCA Protein | +Inquiry |
SNCA-2710H | Recombinant Human SNCA Protein, His-tagged | +Inquiry |
SNCA-2744H | Recombinant Human SNCA protein(11-110 aa), C-His-tagged | +Inquiry |
SNCA-2058H | Recombinant Human SNCA Protein, MYC/DDK-tagged | +Inquiry |
SNCA-8524M | Recombinant Mouse SNCA Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
SNCA-27342TH | Native Human SNCA | +Inquiry |
SNCA-27341TH | Native Human SNCA | +Inquiry |
SNCA-27345TH | Native Human SNCA | +Inquiry |
◆ Lysates | ||
SNCA-1634HCL | Recombinant Human SNCA 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionYes, elevated levels of SNCA protein in cerebrospinal fluid can be indicative of Parkinson's disease.
Therapies may include reducing SNCA aggregation or preventing its misfolding.
Yes, certain mutations in the SNCA gene are associated with familial Parkinson's disease.
Aggregates of misfolded SNCA protein are implicated in various neurodegenerative diseases, including Parkinson's disease.
Yes, several clinical trials are exploring treatments targeting SNCA protein in Parkinson's disease.
Customer Reviews (3)
Write a reviewIts integrity and reliability make it an ideal choice to address the specific objectives of my research.
Their profound knowledge and expertise will undoubtedly help me overcome any challenges that arise, and their prompt assistance ensures a seamless progression of my research.
In addition to the exceptional quality of the protein, the manufacturer's support extends beyond the product itself.
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