Recombinant Human SNRPN cell lysate

• Cat.No.: SNRPN-1658HCL

Specification

• Species: Human
• Tag: Non
• Description: This gene encodes a highly basic protein localized to the nucleus. The evolutionarily constrained open reading frame is found on a bicistronic transcript which has a downstream ORF encoding the small nuclear ribonucleoprotein polypeptide N. The upstream coding region utilizes the first three exons of the transcript, a region that has been identified as an imprinting center. Multiple transcription initiation sites have been identified and extensive alternative splicing occurs in the 5 untranslated region but the full-length nature of these transcripts has not been determined. An alternate exon has been identified that substitutes for exon 4 and leads to a truncated, monocistronic transcript. Alternative splicing or deletion caused by a translocation event in the 5 UTR or coding region of this gene leads to Angelman syndrome or Prader-Willi syndrome due to parental imprint switch failure. The function of this protein is not yet known.
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot

Gene Information

• Gene Name: SNRPN small nuclear ribonucleoprotein polypeptide N [ Homo sapiens ]
• Official Symbol: SNRPN
• Synonyms: SNRPN; small nuclear ribonucleoprotein polypeptide N; Prader Willi syndrome chromosome region , PWCR; small nuclear ribonucleoprotein-associated protein N; HCERN3; RT LI; SM protein N; SM D; small nuclear ribonucleoprotein N; SMN; SNRNP N; SNURF SNRPN; tissue specific splicing protein; sm protein D; tissue-specific splicing protein; tissue-specific-splicing protein; PWCR; SM-D; sm-N; RT-LI; SNRNP-N; SNURF-SNRPN; FLJ33569; FLJ36996; FLJ39265; MGC29886; DKFZp762N022; DKFZp686C0927; DKFZp761I1912; DKFZp686M12165
• Gene ID: 6638
• mRNA Refseq: NM_003097
• Protein Refseq: NP_003088
• MIM: 182279
• UniProt ID: P63162
• Chromosome Location: 15q12
• Pathway: mRNA processing, organism-specific biosystem
• Function: RNA binding; protein binding