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Recombinant Human SOST Protein (Gln24-Tyr213), His-tagged, Biotinylated

Cat.No. : SOST-403H
Product Overview : Recombinant Human SOST Protein (NP_079513.1) (Gln24-Tyr213) was produced by Baculovirus-Insect Cells expression system. This protein was expressed with a polyhistidine tag at the N-terminus. The purified protein was biotinylated in vitro.
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  • Gene Information
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Description : Sclerostin, the protein product of the SOST gene, is a potent inhibitor of bone formation. Sclerostin protein is widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteeoblasts differentiated for 21 days, and was originally identified as an important regulator of bone remodeling, homeostasis, and links bone resorption and bone apposition. Recent studies have revealed that Sclerostin protein inhibits the bone growth probably by binding to the extracellular domain of the Wnt coreceptors LRP5 and LRP6 and disrupting Wnt-induced Frizzled-LRP complex formation.
Source : Baculovirus-Insect Cells
Species : Human
Tag : His
Predicted N Terminal : His
Form : Lyophilized from sterile Sterile PBS. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant SOST consists of 197 amino acids and predicts a molecular mass of 22.5 kDa.
Protein length : Gln24-Tyr213
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 95 % as determined by SDS-PAGE.
Stability : Samples are stable for up to twelve months from date of receipt at -70 centigrade.
Storage : Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Shipping : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Gene Name : SOST sclerostin [ Homo sapiens ]
Official Symbol : SOST
Synonyms : SOST; sclerostin; sclerosteosis; VBCH;
Gene ID : 50964
mRNA Refseq : NM_025237
Protein Refseq : NP_079513
MIM : 605740
UniProt ID : Q9BQB4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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