Recombinant Human SPN Protein, Myc/DDK-tagged, C13 and N15-labeled

Cat.No. : SPN-6532H
Product Overview : SPN MS Standard C13 and N15-labeled recombinant protein (NP_003114) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.
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Description : This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome.
Source : HEK293
Species : Human
Tag : Myc/DDK
Molecular Mass : 40.3 kDa
AA Sequence : MATLLLLLGVLVVSPDALGSTTAVQ TPTSGEPLVSTSEPLSSKMYTTSIT SDPKADSTGDQTSALPPSTSINEGS PLWTSIGASTGSPLPEPTTYQEVSI KMSSVPQETPHATSHPAVPITANSL GSHTVTGGTITTNSPETSSRTSGAP VTTAASSLETSRGTSGPPLTMATVS LETSKGTSGPPVTMATDSLETSTGT TGPPVTMTTGSLEPSSGASGPQVSS VKLSTMMSPTTSTNASTVPFRNPDE NSRGMLPVAVLVALLAVIVLVALLL LWRRRQKRRTGALVLSRGGKRNGVV DAWAGPAQVPEEGAVTVTVGGSGGD KGSGFPDGEGSSRRPTLTTFFGRRK SRQGSLAMEELKSGSGPSLKGEEEP LVASEDGAVDAPAPDEPEGGDGAAP TRTRPLEQKLISEEDLAANDILDYK DDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 3 months from receipt of products under proper storage and handling conditions.
Storage : Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
Concentration : 50 μg/mL as determined by BCA
Storage Buffer : 100 mM glycine, 25 mM Tris-HCl, pH 7.3.
SDS-PAGE:
Gene Name : SPN sialophorin [ Homo sapiens (human) ]
Official Symbol : SPN
Synonyms : SPN; sialophorin; sialophorin (gpL115, leukosialin, CD43); leukosialin; CD43; GPL115; LSN; GALGP; galactoglycoprotein; leukocyte sialoglycoprotein; sialophorin (leukosialin, CD43);
Gene ID : 6693
mRNA Refseq : NM_003123
Protein Refseq : NP_003114
MIM : 182160
UniProt ID : P16150

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the primary role of SPN in immune cell function? 12/29/2022

SPN, or Sialophorin, is important in modulating the function of immune cells, particularly lymphocytes.

What potential therapeutic applications arise from targeting SPN in immune disorders? 12/28/2022

Targeting SPN could provide new treatment approaches for managing immune-related conditions, including autoimmune diseases.

How do genetic variations in SPN affect immune response? 07/10/2019

Genetic changes in SPN can lead to variations in immune cell behavior and effectiveness.

What role does SPN play in cell adhesion and migration? 12/12/2018

SPN plays a role in regulating immune cell adhesion and migration, crucial for immune surveillance and response.

How does SPN interact with other components of the immune system? 05/13/2018

SPN interacts with other immune molecules, coordinating immune cell communication and function.

What is the impact of altered SPN activity on autoimmune diseases? 02/12/2018

Altered SPN activity can impact the regulation of immune responses, potentially leading to autoimmune disorders.

How does SPN contribute to immune cell signaling? 08/11/2017

It contributes to immune cell signaling, influencing cell activation and response to stimuli.

Customer Reviews (3)

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06/23/2023

    Accurate and timely results, crucial for research progress.

    10/02/2018

      Instrumental in our research achievements, highly trusted.

      03/26/2018

        Efficient and dependable, aids our research significantly.

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