Recombinant Human SPTLC2 Protein (88-562 aa), His-SUMO-tagged

• Cat.No.: SPTLC2-818H
• Product Overview: Recombinant Human SPTLC2 Protein (88-562 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cancer. Protein Description: Partial.

Specification

• Description: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 69.7 kDa
• Protein length: 88-562 aa
• AA Sequence: RDFLRYWRIEKCHHATEREEQKDFV SLYQDFENFYTRNLYMRIRDNWNRP ICSVPGARVDIMERQSHDYNWSFKY TGNIIKGVINMGSYNYLGFARNTGS CQEAAAKVLEEYGAGVCSTRQEIGN LDKHEELEELVARFLGVEAAMAYGM GFATNSMNIPALVGKGCLILSDELN HASLVLGARLSGATIRIFKHNNMQS LEKLLKDAIVYGQPRTRRPWKKILI LVEGIYSMEGSIVRLPEVIALKKKY KAYLYLDEAHSIGALGPTGRGVVEY FGLDPEDVDVMMGTFTKSFGASGGY IGGKKELIDYLRTHSHSAVYATSLS PPVVEQIITSMKCIMGQDGTSLGKE CVQQLAENTRYFRRRLKEMGFIIYG NEDSPVVPLMLYMPAKIGAFGREML KRNIGVVVVGFPATPIIESRARFCL SAAHTKEILDTALKEIDEVGDLLQL KYSRHRLVPLLDRPFDETTYEETED
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: SPTLC2 serine palmitoyltransferase, long chain base subunit 2 [ Homo sapiens ]
• Official Symbol: SPTLC2
• Synonyms: SPTLC2; hLCB2a; KIAA0526; LCB2; LCB2A; LCB 2; SPT 2; SPT2; HSN1C; NSAN1C
• Gene ID: 9517
• mRNA Refseq: NM_004863
• Protein Refseq: NP_004854
• MIM: 605713
• UniProt ID: O15270