| Description : |
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
120.7 kDa |
| AA Sequence : |
MTSPAKFKKDKEIIAEYDTQVKEIR AQLTEQMKCLDQQCELRVQLLQDLQ DFFRKKAEIEMDYSRNLEKLAERFL AKTRSTKDQQFKKDQNVLSPVNCWN LLLNQVKRESRDHTTLSDIYLNNII PRFVQVSEDSGRLFKKSKEVGQQLQ DDLMKVLNELYSVMKTYHMYNADSI SAQSKLKEAEKQEEKQIGKSVKQED RQTPRSPDSTANVRIEEKHVRRSSV KKIEKMKEKRQAKYTENKLKAIKAR NEYLLALEATNASVFKYYIHDLSDL IDQCCDLGYHASLNRALRTFLSAEL NLEQSKHEGLDAIENAVENLDATSD KQRLMEMYNNVFCPPMKFEFQPHMG DMASQLCAQQPVQSELVQRCQQLQS RLSTLKIENEEVKKTMEATLQTIQD IVTVEDFDVSDCFQYSNSMESVKST VSETFMSKPSIAKRRANQQETEQFY FTKMKEYLEGRNLITKLQAKHDLLQ KTLGESQRTDCSLARRSSTVRKQDS SQAIPLVVESCIRFISRHGLQHEGI FRVSGSQVEVNDIKNAFERGEDPLA GDQNDHDMDSIAGVLKLYFRGLEHP LFPKDIFHDLMACVTMDNLQERALH IRKVLLVLPKTTLIIMRYLFAFLNH LSQFSEENMMDPYNLAICFGPSLMS VPEGHDQVSCQAHVNELIKTIIIQH ENIFPSPRELEGPVYSRGGSMEDYC DSPHGETTSVEDSTQDVTAEHHTSD DECEPIEAIAKFDYVGRTARELSFK KGASLLLYQRASDDWWEGRHNGIDG LIPHQYIVVQDTEDGVVERSSPKSE IEVISEPPEEKVTARAGASCPSGGH VADIYLANINKQRKRPESGSIRKTF RSDSHGLSSSLTDSSSPGVGASCRP SSQPIMSQSLPKEGPDKCSISGHGS LNSISRHSSLKNRLDSPQIRKTATA GRSKSFNNHRPMDPEVIAQDIEATM NSALNELRELERQSSVKHTPDVVLD TLEPLKTSPVVAPTSEPSSPLHTQL LKDPEPAFQRSASTAGDIACAFRPV KSVKMAAPVKPPATRPKPTVFPKTN ATSPGVNSSTSPQSTDKSCTVSGPT RTRRLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
