Recombinant Human SSB Protein, His-tagged

• Cat.No.: SSB-2737H
• Product Overview: Recombinant Human SSB Protein (Asn4-Glu194) with a N-His tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 26.1 kDa
  Accurate Molecular Mass: 29 kDa
• Protein length: Asn4-Glu194
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: SSB small RNA binding exonuclease protection factor La [ Homo sapiens (human) ]
• Official Symbol: SSB
• Synonyms: SSB; small RNA binding exonuclease protection factor La; La; LARP3; La/SSB; lupus La protein
  La ribonucleoprotein domain family, member 3
  SS-B
  SS-B/La protein
  Sjogren syndrome antigen B
  autoantigen La
  la autoantigen
  lupus La antigen
  sjoegren syndrome type B antigen
• Gene ID: 6741
• mRNA Refseq: NM_003142
• Protein Refseq: NP_003133
• MIM: 109090
• UniProt ID: P05455