Recombinant Human STAM Protein, MYC/DDK-tagged

• Cat.No.: STAM-2850H
• Product Overview: Recombinant Human STAM protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 59 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [ Homo sapiens ]
• Official Symbol: STAM
• Synonyms: STAM-1; STAM1
• Gene ID: 8027
• mRNA Refseq: NM_003473
• Protein Refseq: NP_003464
• MIM: 601899
• UniProt ID: Q92783