Recombinant Human STAT3 protein, His-tagged
Cat.No. : | STAT3-184M |
Product Overview : | Recombinant Human STAT3 protein(P42227)(600aa), fused with His Tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Molecular Mass : | 68.5kDa |
Protein length : | 600aa |
AA Sequence : | MHHHHHHGQA NHPTAAVVTE KQQMLEQHLQ DVRKRVQDLE QKMKVVENLQ DDFDFNYKTL KSQGDMQDLN GNNQSVTRQK MQQLEQMLTA LDQMRRSIVS ELAGLLSAME YVQKTLTDEE LADWKRRQQI ACIGGPPNIC LDRLENWITS LAESQLQTRQ QIKKLEELQQ KVSYKGDPIV QHRPMLEERI VELFRNLMKS AFVVERQPCM PMHPDRPLVI KTGVQFTTKV RLLVKFPELN YQLKIKVCID KDSGDVAALR GSRKFNILGT NTKVMNMEES NNGSLSAEFK HLTLREQRCG NGGRANCDAS LIVTEELHLI TFETEVYHQG LKIDLETHSL PVVVISNICQ MPNAWASILW YNMLTNNPKN VNFFTKPPIG TWDQVAEVLS WQFSSTTKRG LSIEQLTTLA EKLLGPGVNY SGCQITWAKF CKENMAGKGF SFWVWLDNII DLVKKYILAL WNEGYIMGFI SKERERAILS TKPPGTFLLR FSESSKEGGV TFTWVEKDIS GKTQIQSVEP YTKQQLNNMS FAEIIMGYKI MDATNILVSP LVYLYPDIPK EEAFGKYCRP ESQEHPEADP GSAAPYLKTK FICVTPTTCS |
Endotoxin : | < 1EU/μg |
Purity : | >95%(SDS-PAGE & RP-HPLC) |
Storage : | If the sample is used within 2-4 weeks, it can be stored at low temperature at 4°C. For long-term storage, it is recommended to add carrier protein (0.1% HSA or BSA) and store at -20~ -80°C. Avoid multiple freeze-thaws. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Homo sapiens ] |
Official Symbol : | STAT3 |
Synonyms : | STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3; APRF; DNA-binding protein APRF; acute-phase response factor; HIES; FLJ20882; MGC16063; |
Gene ID : | 6774 |
mRNA Refseq : | NM_003150 |
Protein Refseq : | NP_003141 |
MIM : | 102582 |
UniProt ID : | P40763 |
Products Types
◆ Recombinant Protein | ||
STAT3-001H | Recombinant Human STAT3 Protein, His-tagged | +Inquiry |
STAT3-6443H | Recombinant Human STAT3 protein, MBP&His-Avi-tagged, Biotinylated | +Inquiry |
STAT3-31H | Recombinant Human STAT3 protein, His-tagged | +Inquiry |
STAT3-07H | Recombinant Human STAT3 Protein, His-tagged | +Inquiry |
STAT3-2837H | Recombinant Human STAT3 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
STAT3-1418HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
STAT3-1417HCL | Recombinant Human STAT3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewProtein worked well in assay.
Fast shipping, great customer service.
Excellent purity, highly recommend.
Q&As (7)
Ask a questionYes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.
Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.
STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.
Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.
STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.
The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.
STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.
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