Recombinant Human STAT3 protein, His-tagged

Cat.No. : STAT3-184M
Product Overview : Recombinant Human STAT3 protein(P42227)(600aa), fused with His Tag, was expressed in E. coli.
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Source : E. coli
Species : Human
Tag : His
Molecular Mass : 68.5kDa
Protein Length : 600aa
AA Sequence : MHHHHHHGQA NHPTAAVVTE KQQMLEQHLQ DVRKRVQDLE QKMKVVENLQ DDFDFNYKTL
KSQGDMQDLN GNNQSVTRQK MQQLEQMLTA LDQMRRSIVS ELAGLLSAME YVQKTLTDEE
LADWKRRQQI ACIGGPPNIC LDRLENWITS LAESQLQTRQ QIKKLEELQQ KVSYKGDPIV
QHRPMLEERI VELFRNLMKS AFVVERQPCM PMHPDRPLVI KTGVQFTTKV RLLVKFPELN
YQLKIKVCID KDSGDVAALR GSRKFNILGT NTKVMNMEES NNGSLSAEFK HLTLREQRCG
NGGRANCDAS LIVTEELHLI TFETEVYHQG LKIDLETHSL PVVVISNICQ MPNAWASILW
YNMLTNNPKN VNFFTKPPIG TWDQVAEVLS WQFSSTTKRG LSIEQLTTLA EKLLGPGVNY
SGCQITWAKF CKENMAGKGF SFWVWLDNII DLVKKYILAL WNEGYIMGFI SKERERAILS
TKPPGTFLLR FSESSKEGGV TFTWVEKDIS GKTQIQSVEP YTKQQLNNMS FAEIIMGYKI
MDATNILVSP LVYLYPDIPK EEAFGKYCRP ESQEHPEADP GSAAPYLKTK FICVTPTTCS
Endotoxin : < 1EU/μg
Purity : >95%(SDS-PAGE & RP-HPLC)
Storage : If the sample is used within 2-4 weeks, it can be stored at low temperature at 4°C.
For long-term storage, it is recommended to add carrier protein (0.1% HSA or BSA) and store at -20~ -80°C.
Avoid multiple freeze-thaws.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Homo sapiens ]
Official Symbol : STAT3
Synonyms : STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3; APRF; DNA-binding protein APRF; acute-phase response factor; HIES; FLJ20882; MGC16063;
Gene ID : 6774
mRNA Refseq : NM_003150
Protein Refseq : NP_003141
MIM : 102582
UniProt ID : P40763

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
11/17/2022

    Protein worked well in assay.

    04/21/2021

      Fast shipping, great customer service.

      02/06/2018

        Excellent purity, highly recommend.

        Q&As (7)

        Ask a question
        Are there any known inhibitors targeting STAT3 for therapeutic purposes? 02/01/2022

        Yes, there are several inhibitors targeting STAT3, including Stattic, S3I-201, and OPB-31121, which are being explored for their therapeutic potential in cancer and other diseases.

        Can STAT3 activation influence cell proliferation and survival? 11/16/2021

        Yes, activated STAT3 can promote cell proliferation and survival by inducing the expression of genes like cyclin D1 and Bcl-xL.

        How does STAT3 contribute to oncogenesis and tumor progression? 04/12/2021

        STAT3 can contribute to oncogenesis by promoting cell proliferation, survival, angiogenesis, and immune evasion, and by suppressing apoptosis in various cancer types.

        How can the activation of STAT3 be detected in cells? 02/24/2021

        Activation of STAT3 can be detected using Western blotting with phospho-specific antibodies that recognize the tyrosine-phosphorylated form of STAT3.

        How does STAT3 interact with other signaling pathways in the cell? 08/25/2020

        STAT3 can interact with other signaling pathways such as the MAPK, PI3K/AKT, and NF-κB pathways, leading to integrated cellular responses.

        What are the primary upstream activators of STAT3? 01/02/2019

        The primary upstream activators of STAT3 are cytokines and growth factors, especially those that signal through the Janus kinase (JAK) family, such as IL-6 and EGF.

        What role does STAT3 play in immune cell differentiation and function? 04/16/2018

        STAT3 plays a crucial role in the differentiation of Th17 cells, a subset of CD4+ T cells, and is also involved in the function of myeloid-derived suppressor cells (MDSCs) and regulatory T cells, influencing immune responses.

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