Recombinant Human STING R232 variant, Y241A mutant, His tagged

• Cat.No.: STING-04H
• Product Overview: Active recombinant human N-terminal His-tagged STING R232 variant (N242A mutant) expressed in E. coli

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 138-379 aa
• Description: This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
• Form: 50 mM HEPES, pH 8.0, with 100 mM sodium chloride, and 10% glycerol
• Molecular Mass: 28.7 kDa
• Purity: ≥80% estimated by SDS-PAGE
• Storage: At -80 centigrade. Stability: ≥ 1 year
• Shipping: Dry ice in continental US; may vary elsewhere

Gene Information

• Gene Name: STING1 stimulator of interferon response cGAMP interactor 1 [ Homo sapiens (human) ]
• Official Symbol: STING1
• Synonyms: STING1; stimulator of interferon response cGAMP interactor 1; ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta; stimulator of interferon genes protein; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; endoplasmic reticulum IFN stimulator; endoplasmic reticulum interferon stimulator; mitochondrial mediator of IRF3 activation; stimulator of interferon protein; stimulator of interferon response cGAMP interactor-deltaC; stimulator of interferon response cGAMP interactor-deltaN; sting 1; transmembrane protein 173
• Gene ID: 340061
• mRNA Refseq: NM_198282
• Protein Refseq: NP_938023
• MIM: 612374
• UniProt ID: Q86WV6