Recombinant Human Stromal Interaction Molecule 1, CaM-tagged

• Cat.No.: STIM1-344H
• Product Overview: Recombinant Calmodulin tagged STIM was expressed in E.coli and purified by using conventional chromatography techniques (343 aa, 38 kDa).

Specification

• Species: Human
• Source: E.coli
• Description: Stromal interaction molecule 1 (STIM1) is a transmembrane protein that is essential for store-operated Ca(2+) entry, a process of extracellular Ca(2+) influx in response to the depletion of Ca(2+) stores in the endoplasmic reticulum (ER). STIM1 localizes predominantly to the ER; upon Ca(2+) release from the ER, STIM1 translocates to the ER-plasma membrane junctions and activates Ca(2+) channels.
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 7.5).
• Molecular Weight: 38 kDa (343 aa).
• Purity: > 90% by SDS – PAGE.
• Concentration: 1 mg/ml (determined by Bradford assay).
• Sequence: MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAKG SMLSHSHSEK ATGTSSGANS EESTAAEFCR IDKPLCHSED EKLSFEAVRN IHKLMDDDAN GDVDVEESDE FLREDLNYHD PTVKHSTFHG EDKLISVEDL WKAWKSSEVY NWTVDEVVQW LITYVELPQY EETFRKLQLS GHAMPRLAVT NTTMTGTVLK MTDRSHRQKL QLKALDTVLF GPPLLTRHNH LKD
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: STIM1
• Synonyms: STIM1; stromal interaction molecule 1; STIM1 stromal interaction molecule 1; GOK; D11S4896E.
• Gene ID: 6786
• mRNA Refseq: NM_003156.3
• Protein Refseq: NP_003147.2
• MIM: 605921
• UniProt ID: Q13586
• Chromosome Location: 11p15.5
• Pathway: SNARE interactions in vesicular transport; Membrane Trafficking.
• Function: calcium ion binding; protein binding.