| Description : |
Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
61.5 kDa |
| AA Sequence : |
MNKNTSTVVSPSLLEKDPAFQMITI AKETGLGLKVLGGINRNEGPLVYIQ EIIPGGDCYKDGRLKPGDQLVSVNK ESMIGVSFEEAKSIITGAKLRLESA WEIAFIRQKSDNIQPENLSCTSLIE ASGEYGPQASTLSLFSSPPEILIPK TSSTPKTNNDILSSCEIKTGYNKTV QIPITSENSTVGLSNTDVASAWTEN YGLQEKISLNPSVRFKAEKLEMALN YLGIQPTKEQHQALRQQVQADSKGT VSFGDFVQVARNLFCLQLDEVNVGA HEISNILDSQLLPCDSSEADEMERL KCERDDALKEVNTLKEKLLESDKQR KQLTEELQNVKQEAKAVVEETRALR SRIHLAEAAQRQAHGMEMDYEEVIR LLEAKITELKAQLADYSDQNKESVQ DLKKRIMVLDCQLRKSEMARKTFEA STEKLLHFVEAIQEVFSDNSTPLSN LSERRAVLASQTSLTPLGRNGRSIP ATLALESKELVKSVRALLDMDCLPY GWEEAYTADGIKYFINHVTQTTSWI HPVMSVLNLSRSEENEEDCSRELPN QKSTRTRPLEQKLISEEDLAANDIL DYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
