Recombinant Human TACSTD2 protein, Fc-tagged
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|Product Overview :||Recombinant Human TACSTD2 protein (His27-Thr274) was fused to human IgG1 Fc tag at the C-terminus and expressed in human 293 cells (HEK293).|
|Description :||TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.|
|Tag :||human IgG1 Fc|
|Predicted N Terminal :||His27|
|Form :||Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.|
|Molecular Mass :||The protein has a calculated MW of 54.3 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||His27-Thr274|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.|
|SDS-PAGE of TACSTD2-416H :||
Human TROP-2, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
|Gene Name :||TACSTD2|
|Official Symbol :||TACSTD2|
|Synonyms :||EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1|
|Gene ID :||4070|
|mRNA Refseq :||NM_002353.3|
|Protein Refseq :||NP_002344.2|
|UniProt ID :||P09758|
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