Recombinant Human TACSTD2 protein, Fc-tagged

• Cat.No.: TACSTD2-416H
• Product Overview: Recombinant Human TACSTD2 protein (His27-Thr274) was fused to human IgG1 Fc tag at the C-terminus and expressed in human 293 cells (HEK293).

Specification

• Description: TROP-2 is a single-copy gene in human cells, and encodes a type-1 transmembrane glycoprotein which is over-expressed in various malignancies, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells.
• Source: HEK293
• Species: Human
• Tag: human IgG1 Fc
• Predicted N Terminal: His27
• Form: Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 54.3 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Protein length: His27-Thr274
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20°C or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20°C to -70°C for 12 months in lyophilized state;
  -70°C for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: TACSTD2
• Official Symbol: TACSTD2
• Synonyms: EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1
• Gene ID: 4070
• mRNA Refseq: NM_002353.3
• Protein Refseq: NP_002344.2
• MIM: 137290
• UniProt ID: P09758