Recombinant Human TANK Protein (1-119 aa), His-tagged

• Cat.No.: TANK-1531H
• Product Overview: Recombinant Human TANK Protein (1-119 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Signal Transduction. Protein Description: Partial.

Specification

• Description: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining th in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
• Source: Yeast
• Species: Human
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 15.8 kDa
• Protein length: 1-119 aa
• AA Sequence: MDKNIGEQLNKAYEAFRQACMDRDS AVKELQQKTENYEQRIREQQEQLSL QQTIIDKLKSQLLLVNSTQDNNYGC VPLLEDSETRKNNLTLDQPQDKVIS GIAREKLPKVRRQEVSSPR
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: TANK TRAF family member-associated NFKB activator [ Homo sapiens ]
• Official Symbol: TANK
• Synonyms: TANK; TRAF2; I TRAF; TRAF-interacting protein; I-TRAF
• Gene ID: 10010
• mRNA Refseq: NM_004180
• Protein Refseq: NP_004171
• MIM: 603893
• UniProt ID: Q92844