Recombinant Human Tau-441 (2N4R) Wild-Type Protein (Pre-formed Fibrils)

• Cat.No.: MAPT-13H
• Product Overview: Human Recombinant Tau-441 (2N4R) Wild-Type Protein Pre-formed Fibrils without tag was expressed in E. coli.

Specification

• Description: This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
• Source: E.coli
• Species: Human
• Protein Length: Full Length
• AA Sequence: MAEPRQEFEVMEDHAGTYGLGDRKD QGGYTMHQDQEGDTDAGLKESPLQT PTEDGSEEPGSETSDAKSTPTAEDV TAPLVDEGAPGKQAAAQPHTEIPEG TTAEEAGIGDTPSLEDEAAGHVTQA RMVSKSKDGTGSDDKKAKGADGKTK IATPRGAAPPGQKGQANATRIPAKT PPAPKTPPSSGEPPKSGDRSGYSSP GSPGTPGSRSRTPSLPTPPTREPKK VAVVRTPPKSPSSAKSRLQTAPVPM PDLKNVKSKIGSTENLKHQPGGGKV QIINKKLDLSNVQSKCGSKDNIKHV PGGGSVQIVYKPVDLSKVTSKCGSL GNIHHKPGGGQVEVKSEKLDFKDRV QSKIGSLDNITHVPGGGNKKIETHK LTFRENAKAKTDHGAEIVYKSPVVS GDTSPRHLSNVSSTGSIDMVDSPQL ATLADEVSASLAKQGL
• Purity: > 95%
• Applications: WB, SDS-PAGE, In vivo assay, In vitro assay
• Storage: At -80 centigrade
• Storage Buffer: 10 mM HEPES, 100 mM NaCl pH 7.4
• Shipping: Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

Gene Information

• Gene Name: MAPT microtubule associated protein tau [ Homo sapiens (human) ]
• Official Symbol: MAPT
• Synonyms: Active tau PFFs, tau PFF, active tau protein Pre-formed Fibrils, active tau aggregates, microtubule-associated protein tau, MAPT, MAP, microtubule-associated protein, Paired Helical Filament-Tau, Phf-Tau, Neurofibrillary Tangle Protein, G Protein Beta1/Gamma2 Subunit-Interacting Factor 1, Isoform 4, tubulin-associated unit, MAPT DeltaK280, ΔK280 tau, K18 delta K280 tau, truncated ΔK280 tau; MAPT; microtubule associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; tau-40; FTDP-17; PPP1R103; Tau-PHF6; microtubule-associated protein tau; G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; Tau-derived paired helical filament hexapeptide; neurofibrillary tangle protein; paired helical filament-tau; protein phosphatase 1, regulatory subunit 103
• Gene ID: 4137
• mRNA Refseq: NM_016841
• Protein Refseq: NP_058525
• MIM: 157140
• UniProt ID: P10636