MAPT

  • Official Full Name

    microtubule-associated protein tau

  • Overview

    This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimers disease, Picks disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
  • Synonyms

    MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Mamanlian cells
  • Mammalian Cell
  • Yeast
  • C
  • His
  • Myc
  • DDK
  • Flag
  • His|SUMO
  • His|T7
  • Myc|DDK
  • N/A
  • N
  • AVI
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPT-2874H Recombinant Human MAPT, His-tagged E.coli His
Human MAPT-30090TH Recombinant Human MAPT E.coli N/A
Human MAPT-528H Recombinant Human MAPT protein(Ala2-Leu352), His-tagged E. coli N-His
Human MAPT-5074H Recombinant Human Microtubule-Associated Protein Tau, His-tagged Human His
Human MAPT-1572H Recombinant Human Microtubule-Associated Protein Tau E.coli N/A
Human MAPT-30091TH Recombinant Human MAPT E.coli N/A
Human MAPT-5073H Recombinant Human Microtubule-Associated Protein Tau, His-tagged Human His
Human MAPT-121H Recombinant Human Tau-441 (1-391) E.coli N/A
Human MAPT-158H Recombinant Human Tau-441 (50-441) E.coli N/A
Human MAPT-97H Recombinant Human MAPT E.coli N/A
Human MAPT-168H Recombinant Human Tau-441 (127-421) E.coli N/A
Human MAPT-169H Recombinant Human Tau-441 (151-391) E.coli N/A
Human MAPT-173H Recombinant Human Tau-441 (99-441) E.coli N/A
Human MAPT-98H Recombinant Human MAPT E.coli N/A
Human MAPT-122H Recombinant Human Tau-441 (1-421) E.coli N/A
Human MAPT-189H Recombinant Human Tau-441 (244-372) E.coli N/A
Human MAPT-133H Recombinant Human Tau-441 (dK280) E.coli N/A
Human MAPT-100H Recombinant Human MAPT E.coli N/A
Human MAPT-172H Recombinant Human Tau-441 (231-441) E.coli N/A
Human MAPT-157H Recombinant Human Tau-441 (50-421) E.coli N/A
Human MAPT-134H Recombinant Human Tau-441 (dN296) E.coli N/A
Human MAPT-49H Recombinant Human MAPT (N352H) E.coli N/A
Human MAPT-156H Recombinant Human Tau-441 (50-391) E.coli N/A
Human MAPT-123H Recombinant Human Tau-441 (G272V) E.coli N/A
Human MAPT-144H Recombinant Human Tau-441 (S352L) E.coli N/A
Human MAPT-170H Recombinant Human Tau-441 (151-421) E.coli N/A
Human MAPT-124H Recombinant Human Tau-441 (K257T) E.coli N/A
Human MAPT-135H Recombinant Human Tau-441 (L266V) E.coli N/A
Human MAPT-145H Recombinant Human Tau-441 (S404A) E.coli N/A
Human MAPT-171H Recombinant Human Tau-441 (151-441) E.coli N/A
Human MAPT-125H Recombinant Human Tau-441 (N279K) E.coli N/A
Human MAPT-141H Recombinant Human Tau-441 (S199E) E.coli N/A
Human MAPT-146H Recombinant Human Tau-441 (S404E) E.coli N/A
Human MAPT-186H Recombinant Human Tau-441 (216-391) E.coli N/A
Human MAPT-140H Recombinant Human Tau-441 (S198E) E.coli N/A
Human MAPT-143H Recombinant Human Tau-441 (S305N) E.coli N/A
Human MAPT-159H Recombinant Human Tau-441 (V337M) E.coli N/A
Human MAPT-187H Recombinant Human Tau-441 (231-391) E.coli N/A
Human MAPT-142H Recombinant Human Tau-441 (S214A) E.coli N/A
Human MAPT-21H Recombinant Human MAPT protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAPT-38H Recombinant Human Tau-441 protein, phosphorylated E.coli N/A
Human MAPT-188H Recombinant Human Tau-441 (231-421) E.coli N/A
Human MAPT-20H Recombinant Human MAPT protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAPT-30093TH Recombinant Human MAPT E.coli N/A
Human MAPT-204H Recombinant Human MAPT(A152T) protein E.coli N/A
Human MAPT-136H Recombinant Human Tau-441 (P301L) E.coli N/A
Human MAPT-30138TH Recombinant Human MAPT E.coli N/A
Human MAPT-94H Recombinant Human MAPT E.coli N/A
Human MAPT-218H Recombinant Human MAPT E.coli N/A
Human MAPT-137H Recombinant Human Tau-441 (P301S) E.coli N/A
Human MAPT-95H Recombinant Human MAPT E.coli N/A
Human MAPT-96H Recombinant Human MAPT E.coli N/A
Human MAPT-138H Recombinant Human Tau-441 (R406W) E.coli N/A
Human MAPT-127H Recombinant Human MAPT Protein, His-tagged E.coli His
Human MAPT-139H Recombinant Human Tau-441 (S198A) E.coli N/A
Human MAPT-4477HCL Recombinant Human MAPT 293 Cell Lysate HEK293 N/A
Human MAPT-4476HCL Recombinant Human MAPT 293 Cell Lysate HEK293 N/A
Human MAPT-4478HCL Recombinant Human MAPT 293 Cell Lysate HEK293 N/A
Human MAPT-22H Recombinant Human SAMHD1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human MAPT-516H Active Recombinant Human MAPT Protein E. coli
Human MAPT-4220HFL Recombinant Full Length Human MAPT protein, Flag-tagged Mamanlian cells Flag
Human MAPT-555H Recombinant Human MAPT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPT-2212H Recombinant Human MAPT protein, His-tagged E.coli His
Human MAPT-3001H Recombinant Human MAPT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPT-39H Recombinant Human MAPT Protein (216-391), N-AVI-tagged, Biotinylated E.coli N-AVI
Human MAPT-4497H Recombinant Human MAPT Protein (Met1-Leu758), N-His tagged E.coli N-His
Human MAPT-13H Recombinant Human Tau-441 (2N4R) Wild-Type Protein (Pre-formed Fibrils) E.coli
Human MAPT-4383H Recombinant Human MAPT protein, His-tagged E.coli His
Human MAPT-4498H Recombinant Human MAPT Protein (Gly243-Pro372), N-His tagged E.coli N-His
Human MAPT-4499H Recombinant Human MAPT Protein (Met1-Ala166), N-His tagged E.coli N-His
Human MAPT-032H Recombinant Human MAPT Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human MAPT-52H Recombinant Human MAPT Protein, His-tagged HEK293 His
Human MAPT-53H Recombinant Human MAPT Protein E.coli
Human MAPT-4495H Recombinant Human MAPT Protein (Ala249-Lys381), C-His tagged E.coli C-His
Human MAPT-4496H Recombinant Human MAPT Protein E.coli
Mouse Mapt-20M Recombinant Mouse Mapt protein, His-tagged Yeast His
Mouse Mapt-19M Recombinant Mouse Mapt protein, His-tagged E.coli His
Mouse Mapt-3953M Recombinant Mouse Mapt Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Mapt-2062R Recombinant Rat Mapt protein, His & T7-tagged E.coli His/T7
Rat MAPT-647R Recombinant Rat MAPT Protein (2-752 aa), His-tagged E.coli His
Rat MAPT-648R Recombinant Rat MAPT Protein, His-tagged Yeast His
Cynomolgus MAPT-01C Recombinant Cynomolgus MAPT Protein, His tagged E.coli C-His
Cynomolgus MAPT-02C Recombinant Cynomolgus MAPT Protein, His tagged HEK293 C-His
Rhesus Macaque MAPT-646R Recombinant Rhesus Macaque MAPT Protein (2-459 aa), His-SUMO-tagged E.coli His/SUMO
Chicken MAPT-4246C Recombinant Chicken MAPT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAPT Related Articles
  • MAPT Related Research Area

MAPT involved in several pathways and played different roles in them. We selected most pathways MAPT participated on our site, such as MAPK signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPP3R1B;RPS6KA2;FGF4;FGF20B;GNG12;RPS6KA5;PLA2G4D;PDGFA;FGF12
Alzheimers diseaseGSK3B;PLCB1;COX6A2;NDUFS4;NDUFA8;MAPK1;NDUFA4L2;LRP1;NDUFS2

MAPT has several biochemical functions, for example, SH3 domain binding, apolipoprotein binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPT itself. We selected most functions MAPT had, and list some proteins which have the same functions with MAPT. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingARHGAP31;DTX1;QK;INPPL1;VASPA;PTPN12;SH3BGR;NCF1;SKAP1
apolipoprotein bindingLPA;LRP6;CANX;SCARB1;MAPT;PCSK9;ABCA1;LRP1;LRP4
enzyme bindingNFKBIA;CUTA;UGT1A4;GBP1;CYP2C8;PPP3CB;HINFP;CBX3;ERN1
lipoprotein particle bindingCDH13;GPIHBP1;MAPT;APOE
microtubule bindingKIF12;NUSAP1;MAPRE3B;WDR43;KIF4;CLIP1;KIF5B;NEFH;SNCA
protein bindingS100A9;KIF21A;MMP20;ARMCX5-GPRASP2;RPL11;NLRP2;OPRM1;MPP2;CASKIN1
protein kinase bindingBCL2L14;TRAF2;FBXW5;PPP1CB;PTK2;FBXO7;TEX14;GCET2;FOXO3
protein phosphatase 2A bindingCTTNBP2NL;EIF4EBP1;SMG5;GRIN3A;ENSA;ANKLE2;PPP2R2A;RPS6KB1;MASTL
structural constituent of cytoskeletonNEFH;TLN2A;TUBA8L2;NEFM;KRT20;AGRN;DMD;BICD1;KRT15

MAPT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPT here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPT.

YWHAZ; APP; MARK2; APOE

Xu, H; Rosler, TW; et al. Memory deficits correlate with tau and spine pathology in P301S MAPT transgenic mice. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY 40:833-843(2014).
Karageorgiou, E; Miller, BL; et al. Frontotemporal Lobar Degeneration: A Clinical Approach. SEMINARS IN NEUROLOGY 34:189-201(2014).
  • Q&As
  • Reviews

Q&As (6)

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How to assess the degree of abnormal aggregation of MAPT protein? 12/13/2019

The degree of abnormal aggregation of MAMAP proteins can be assessed by a variety of methods, such as immunohistochemistry, immunofluorescence staining, Western blot, etc. These methods can detect and quantify abnormally aggregated MAPT proteins.

What is the relationship between MAPT protein and nerve cytoskeleton? 11/30/2019

The MAPT protein is closely related to the nerve cytoskeleton. It is involved in regulating axon formation and maintenance, cytosolic flow, and the normal function of neurons by binding and stabilizing microtubules.

What are the interactions of the MAPT protein with other proteins in the nervous system? 10/24/2019

MAPT protein interacts with other proteins in the nervous system, such as α-synuclein, β-kinigin, etc. These interactions may be involved in regulating the structure and function of neurons.

Is there a mechanism that regulates the expression of MAPT protein? 10/21/2019

Yes, the expression of MAPT protein is affected by a variety of regulatory mechanisms, including transcriptional regulation, splicing regulation, phosphorylation regulation, etc. These regulatory mechanisms are essential for maintaining normal MAPT protein levels and function.

What are the future directions for MAPT protein research? 07/06/2019

Future research directions include further elucidating the mechanism of abnormal aggregation and phosphorylation of MAPT protein, exploring the pathogenesis of genetic diseases associated with MAPT gene, finding therapeutic strategies to intervene in abnormal aggregation of MATT, and developing biomarkers related to MAPT protein for early diagnosis and therapeutic monitoring.

How about the applications of MAPT protein in clinical diagnosis? 07/05/2019

The MAPT protein plays an important role in clinical diagnosis. By measuring the level of the MAPT protein in the blood or cerebrospinal fluid, it can help identify different types of neurodegenerative diseases, such as Alzheimer's disease and prefrontal temporal dementia.

Customer Reviews (3)

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Reviews
07/22/2022

    Western-blot experiments using MAPT as a target have shown highly reproducible results.

    08/08/2020

      This stability of MAPT is very good and can maintain its original properties even after multiple uses.

      09/15/2019

        MAPT's purity and consistency make it a top choice for Western-blot experiments.

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