MAPT
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Official Full Name
microtubule-associated protein tau
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Overview
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimers disease, Picks disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008] -
Synonyms
MAPT; microtubule-associated protein tau; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; G protein beta1/gamma2 subunit-interacting factor 1;
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- Avi
- Flag
- His
- SUMO
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
MAPT involved in several pathways and played different roles in them. We selected most pathways MAPT participated on our site, such as MAPK signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF1A;MKNK2;FLNA;PDGFAA;GRB2;PDGFAB;ARRB2;ARRB1;MAP4K3 |
| Alzheimers disease | EIF2AK3;CAPN2;NDUFA13;ATP5O;PLCB2;GRIN2D;NDUFS3;BAD;MAPK1 |
MAPT has several biochemical functions, for example, SH3 domain binding, apolipoprotein binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPT itself. We selected most functions MAPT had, and list some proteins which have the same functions with MAPT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | ARHGAP17;DENND1A;SH3BGRL2;ABI2;SH3BP1;MVB12A;SHANK2;ADAM9;PLSCR4 |
| apolipoprotein binding | LRP6;LPL;ABCA1;LRP4;SCARB1;MAPT;PCSK9;PLG;CANX |
| enzyme binding | TSPAN15;BCL10;TMBIM6;PLSCR1;CNTNAP2;HOXA9;A2M;MLL5;RXRA |
| lipoprotein particle binding | GPIHBP1;CDH13;MAPT;APOE |
| microtubule binding | MACF1;PRC1;TPPP;TXNDC3;KCNH2A;KIF2A;FGF13;KIF18B;KIFC2 |
| protein binding | PPID;ABCD2;INTS4;CCDC36;JUNB;NXF3;SCAMP1;SEC24D;BSX |
| protein kinase binding | PRKCZ;BCAR1;VDAC1;KIF20A;TTN;MAP3K1;CADPS;AKAP5;CCNY |
| protein phosphatase 2A binding | STRN4;ARPP19;IGBP1;EIF4EBP1;FOXO1;PPME1;TP53;ANKLE2;RPS6KB1 |
| structural constituent of cytoskeleton | ANK1;TUBA4A;NDC80;TLN2A;NEFH;TUBB5;SPTBN2;SPRR2A1;ACTG1 |
MAPT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPT here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPT.
YWHAZ; APP; MARK2; APOE
Research Area
Related articles
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Customer Reviews (3)
Write a reviewWestern-blot experiments using MAPT as a target have shown highly reproducible results.
This stability of MAPT is very good and can maintain its original properties even after multiple uses.
MAPT's purity and consistency make it a top choice for Western-blot experiments.
Q&As (6)
Ask a questionThe degree of abnormal aggregation of MAMAP proteins can be assessed by a variety of methods, such as immunohistochemistry, immunofluorescence staining, Western blot, etc. These methods can detect and quantify abnormally aggregated MAPT proteins.
The MAPT protein is closely related to the nerve cytoskeleton. It is involved in regulating axon formation and maintenance, cytosolic flow, and the normal function of neurons by binding and stabilizing microtubules.
MAPT protein interacts with other proteins in the nervous system, such as α-synuclein, β-kinigin, etc. These interactions may be involved in regulating the structure and function of neurons.
Yes, the expression of MAPT protein is affected by a variety of regulatory mechanisms, including transcriptional regulation, splicing regulation, phosphorylation regulation, etc. These regulatory mechanisms are essential for maintaining normal MAPT protein levels and function.
Future research directions include further elucidating the mechanism of abnormal aggregation and phosphorylation of MAPT protein, exploring the pathogenesis of genetic diseases associated with MAPT gene, finding therapeutic strategies to intervene in abnormal aggregation of MATT, and developing biomarkers related to MAPT protein for early diagnosis and therapeutic monitoring.
The MAPT protein plays an important role in clinical diagnosis. By measuring the level of the MAPT protein in the blood or cerebrospinal fluid, it can help identify different types of neurodegenerative diseases, such as Alzheimer's disease and prefrontal temporal dementia.
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