Recombinant Human Tax1 (Human T-Cell Leukemia Virus Type I) Binding Protein 3, His-tagged

• Cat.No.: TAX1BP3-4742H
• Product Overview: Recombinant human TAX1BP3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Specification

• Species: Human
• Source: Human
• Tag: His
• Description: TAX1BP3, also known as Tax1-binding protein 3, contains one PDZ domain, through which most of its interactions with other proteins are made. The PDZ domain of TAX1BP3 interacts with the C-terminus of Rhotekin to facilitate Rho-mediated activation of the FOS serum response element. The PDZ domain also interacts with beta-catenin to inhibit the transcriptional activity of beta-catenin. It has been detected in a variety of cell lines, including HeLa, and is weakly expressed in peripheral blood leukocytes.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT
• Molecular Weight: 15.8 kDa (144aa), confirmed by MALDI-TOF
• Purity: > 95% by SDS - PAGE
• Concentration: 1.0 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MSYIPGQPVT AVVQRVEIHK LRQGENLILG FSIGGGIDQD PSQNPFSEDK TDKGIYVTRV SEGGPAEIAG LQIGDKIMQV NGWDMTMVTH DQARKRLTKR SEEVVRLLVT RQSLQKAVQQ SMLS
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Wnt Signaling Pathway NetPath

Gene Information

• Gene Name: TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 [ Homo sapiens ]
• Official Symbol: TAX1BP3
• Synonyms: TAX1BP3; TIP-1; tax1-binding protein 3; OTTHUMP00000115871; Tax interaction protein 1; glutaminase-interacting protein 3; Tax1 (human T-cell leukemia virus type I) binding protein 3; Glutaminase-interacting protein 3; TIP1
• Gene ID: 30851
• mRNA Refseq: NM_014604
• Protein Refseq: NP_055419
• UniProt ID: O14907
• Chromosome Location: 17p13
• Function: beta-catenin binding; protein C-terminus binding; protein binding