Recombinant Human TCHP Protein (1-498 aa), His-SUMO-tagged

• Cat.No.: TCHP-1134H
• Product Overview: Recombinant Human TCHP Protein (1-498 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Cancer. Protein Description: Full Length.

Specification

• Description: Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 77.1 kDa
• Protein length: 1-498 aa
• AA Sequence: MALPTLPSYWCSQQRLNQQLARQRE QEARLRQQWEQNSRYFRMSDICSSK QAEWSSKTSYQRSMHAYQREKMKEE KRRSLEARREKLRQLMQEEQDLLAR ELEELRLSMNLQERRIREQHGKLKS AKEEQRKLIAEQLLYEHWKKNNPKL REMELDLHQKHVVNSWEMQKEEKKQ QEATAEQENKRYENEYERARREALE RMKAEEERRQLEDKLQAEALLQQME ELKLKEVEATKLKKEQENLLKQRWE LERLEEERKQMEAFRQKAELGRFLR HQYNAQLSRRTQQIQEELEADRRIL QALLEKEDESQRLHLARREQVMADV AWMKQAIEEQLQLERAREAELQMLL REEAKEMWEKREAEWARERSARDRL MSEVLTGRQQQIQEKIEQNRRAQEE SLKHREQLIRNLEEVRELARREKEE SEKLKSARKQELEAQVAERRLQAWE ADQQEEEEEEEARRVEQLSDALLQQ EAETMAEQGYRPKPYGHPKIAWN
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: TCHP trichoplein, keratin filament binding [ Homo sapiens ]
• Official Symbol: TCHP
• Synonyms: TCHP; MGC10854; mitostatin; TpMs
• Gene ID: 84260
• mRNA Refseq: NM_001143852
• Protein Refseq: NP_001137324
• MIM: 612654
• UniProt ID: Q9BT92