Recombinant Human TDG Protein, His-tagged
| Cat.No. : | TDG-122H |
| Product Overview : | Recombinant Human TDG Protein, fused to His-tag, was expressed in E. coli. |
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| Species : | Human |
| Source : | E.coli |
| Tag : | His |
| Description : | The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. |
| Form : | 50mM Tris, 300mM NaCl, pH8.0. |
| Molecular Mass : | 26.5 kDa |
| AA Sequence : | MDDATNKKRKVFVSTILTFWNTDRRDFPWRHTRDPYVILITEILLRRTTAGHVKKIYDKFFVKYKCFEDILKTPKSEIAKDIKEIGLSNQRAEQLKELARVVINDYGGRVPRNRKAILDLPGVGKYTCAAVMCLAFGKKAAMVDANFVRVINRYFGGSYENLNYNHKALWELAETLVPGGKCRDFNLGLMDFSAIICAPRKPKCEKCGMSKLCSYYEKCSTLEHHHHHH |
| Purity : | >90% |
| Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Concentration : | 0.2 mg/ml |
| Gene Name | TDG thymine DNA glycosylase [ Homo sapiens (human) ] |
| Official Symbol | TDG |
| Synonyms | hTDG |
| Gene ID | 6996 |
| mRNA Refseq | NM_001363612 |
| Protein Refseq | NP_001350541 |
| MIM | 601423 |
| UniProt ID | Q13569 |
Not For Human Consumption!
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