Recombinant Human Tec Protein Tyrosine Kinase, GST-tagged

• Cat.No.: TEC-2621H
• Product Overview: Recombinant Human TEC, catalytic domain [359-631 amino acids] was expressed as N-terminal GST-fusion protein (59 kDa) usingbaculovirusexpression system. GST-TEC was purified by using glutathione sepharose chromatography and anion exchange chromatography.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 359-631 a.a.
• Description: The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.
• Purity: 100%. The purity was assessed by SDS-PAGE/CBB staining.
• Storage Buffer: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5.
• ATP: 100μM.
• Substrate: Srctide.
• Storage: Store at -80℃. Avoid repeating freeze-thaws.

Gene Information

• Gene Name: TEC tec protein tyrosine kinase [ Homo sapiens ]
• Synonyms: TEC; tec protein tyrosine kinase; PSCTK4; MGC126760; MGC126762; tyrosine-protein kinase Tec; EC 2.7.10.2
• Gene ID: 7006
• mRNA Refseq: NM_003215
• Protein Refseq: NP_003206
• MIM: 600583
• UniProt ID: P42680
• Chromosome Location: 4p12
• Pathway: T cell receptor signaling pathway
• Function: ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity