Recombinant Human TET2 Protein, FLAG/His-tagged
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| Cat.No. : | TET2-01H |
| Product Overview : | Recombinant human TET2 protein (a.a. 1129-2002 (end)) with N-terminal FLAG tag and C-terminal His tag was expressed in Sf9 cells via a baculovirus expression system. |
| Description : | The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. |
| Source : | Insects Cell |
| Species : | Human |
| Tag : | FLAG/His |
| Molecular Mass : | 100 kDa |
| Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Storage : | At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. |
| Concentration : | 0.81 mg/mL |
| Storage Buffer : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 3 mM DTT and 400 mM imidazole. |
| Gene Name : | TET2 tet methylcytosine dioxygenase 2 [ Homo sapiens (human) ] |
| Official Symbol : | TET2 |
| Synonyms : | TET2; tet methylcytosine dioxygenase 2; MDS; KIAA1546; methylcytosine dioxygenase TET2; probable methylcytosine dioxygenase TET2; tet oncogene family member 2; EC 1.14.11.n2 |
| Gene ID : | 54790 |
| mRNA Refseq : | NM_001127208 |
| Protein Refseq : | NP_001120680 |
| MIM : | 612839 |
| UniProt ID : | Q6N021 |
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