Recombinant Human TET2 Protein, FLAG/His-tagged

• Cat.No.: TET2-01H
• Product Overview: Recombinant human TET2 protein (a.a. 1129-2002 (end)) with N-terminal FLAG tag and C-terminal His tag was expressed in Sf9 cells via a baculovirus expression system.

Specification

• Description: The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene.
• Source: Insects Cell
• Species: Human
• Tag: FLAG/His
• Molecular Mass: 100 kDa
• Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
• Storage: At least 6 months at –80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.81 mg/mL
• Storage Buffer: 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, 3 mM DTT and 400 mM imidazole.

Gene Information

• Gene Name: TET2 tet methylcytosine dioxygenase 2 [ Homo sapiens (human) ]
• Official Symbol: TET2
• Synonyms: TET2; tet methylcytosine dioxygenase 2; MDS; KIAA1546; methylcytosine dioxygenase TET2; probable methylcytosine dioxygenase TET2; tet oncogene family member 2; EC 1.14.11.n2
• Gene ID: 54790
• mRNA Refseq: NM_001127208
• Protein Refseq: NP_001120680
• MIM: 612839
• UniProt ID: Q6N021