Recombinant Human THAP Domain Containing, Apoptosis Associated Protein 1, His-tagged

• Cat.No.: THAP1-5594H
• Product Overview: Recombinant humanTHAP1 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: THAPdomain-containing protein 1, also known as THAP1, is a 213 amino acid proteinthat localizes to the nucleoplasm and contains one THAPtype zinc finger, aconserved DNA-binding domain. It is a DNA-binding transcription regulatorthat regulates endothelial cell proliferation and G1/S cell-cycleprogression. THAP1 may also have pro-apoptopic activity by potentiating bothserum-withdrawal and TNF-induced apoptosis.
• Form: Liquid. In 20mMTris-HCl buffer (pH 8.0) containing 2M Urea, 10% glycerol, 1mM DTT, 0.2M NaCl.
• Molecular Weight: 27.5 kDa(237aa)
• Purity: > 85%by SDS-PAGE
• Concentration: 1 mg/ml(determined by Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMVQSCS AYGCKNRYDK DKPVSFHKFP LTRPSLCKEW EAAVRRKNFKPTKYSSICSE HFTPDCFKRE CNNKLLKENA VPTIFLCTEP HDKKEDLLEP QEQLPPPPLP PPVSQVDAAIGLLMPPLQTP VNLSVFCDHN YTVEDTMHQR KRIHQLEQQV EKLRKKLKTA QQRCRRQERQ LEKLKEVVHFQKEKDDVSER GYVILPNDYF EIVEVPA
• Storage: Can bestored at +4°C short term (1-2 weeks). For long term storage, aliquot andstore at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: THAP1 THAP domain containing,apoptosis associated protein 1 [ Homo sapiens ]
• Official Symbol: THAP1
• Synonyms: THAP1; THAP domain containing, apoptosisassociated protein 1; DYT6; FLJ10477; MGC33014; THAP domain-containingprotein 1; 4833431A01Rik; THAP domain protein 1; nuclear proapoptotic factor;dystonia 6, torsion (autosomal dominant); OTTHUMP00000229191;OTTHUMP00000229192; OTTHUMP00000229193
• Gene ID: 55145
• mRNA Refseq: NM_018105
• Protein Refseq: NP_060575
• MIM: 609520
• UniProt ID: Q9NVV9
• Chromosome Location: 8p11.21
• Function: metal ion binding; sequence-specific DNAbinding; zinc ion binding