Recombinant Human TIE1, Fc Chimera

• Cat.No.: TIE1-2531H
• Product Overview: Recombinant human TIE1 fused to Fc Chimera, was expressed inNSO.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc
• Description: Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie-1) are novel endothelial cell tyrosine kinase receptors that are essential for vascular development and remodeling in the embryo. They are expressed almost exclusively in endothelial cells. Tie-1 also have a role in the regulatory pathways of early hematopoiesis and angiogenesis. It is upregulated in diseases such as atherosclerosis and rheumatoid arthritis.
• Biochem/physiol Actions: Tie (tyrosine kinase with Ig and EGF homology domains) receptors Tie-1 and Tie-2 are receptor tyrosine kinase (RTK) family members with unique structural characteristics that involve their two Ig-like, three EGF-like and three fibronectin III-like motifs in the extracellular domain. They also have a split tyrosine kinase domain in the cytoplasmic region. They are expressed primarily on endothelial cells and hematopoietic progenitors. Tie-1 and Tie-2 are thought to play critical roles in angiogenesis and hematopoiesis. Tie-1 is related to endothelial cell differentiation and maintenance of endothelium integrity.
• Physical Form: Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
• Assay: ≥90% (SDS-PAGE).
• Form: lyophilized powder.
• Total Impurities: endotoxin, tested.
• Suitability: cell culture tested.
• Storage Temp: −20°C.

Gene Information

• Gene Name: TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [ Homo sapiens ]
• Synonyms: TIE1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; receptor tyrosine kinase; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; EC 2.7.10.1; JTK14; TIE; Tyrosine-protein kinase receptor Tie-1; OTTHUMP00000008352
• Gene ID: 7075
• mRNA Refseq: NM_005424
• Protein Refseq: NP_005415
• MIM: 600222
• UniProt ID: P35590
• Chromosome Location: 1p34-p33
• Function: ATP binding; nucleotide binding; protein binding; receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity