Recombinant Human TIGIT Protein, C-6His-Avi tagged, Biotinylated
Cat.No. : | TIGIT-12H |
Product Overview : | Biotinylated Recombinant Human T cell Immunoreceptor with Ig and ITIM domains is produced by our Mammalian expression system and the target gene encoding Met22-Pro141 is expressed with a 6His, Avi tag at the C-terminus. |
- Specification
- Gene Information
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Description : | T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated, memory and regulatory T cells, and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation, while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2, which also interact with DNAM-1/CD226 and CD96/Tactile, TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular, TIGIT binding to CD155 can antagonize the effects of DNAM1. |
Source : | Human Cells |
Species : | Human |
Tag : | C-6His-Avi |
Protein Length : | Met22-Pro141 |
Endotoxin : | Less than 0.1 ng/μg (1 EU/μg) |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. |
Shipping : | Ambient |
Gene Name : | TIGIT T cell immunoreceptor with Ig and ITIM domains [ Homo sapiens (human) ] |
Official Symbol : | TIGIT |
Synonyms : | T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9 |
Gene ID : | 201633 |
mRNA Refseq : | NM_173799 |
Protein Refseq : | NP_776160 |
MIM : | 612859 |
UniProt ID : | Q495A1 |
Products Types
◆ Recombinant Protein | ||
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TIGIT-1144C | Recombinant Cynomolgus TIGIT Protein (Met1-Pro209), HlgG1 Fc-tagged | +Inquiry |
TIGIT-356H | Active Recombinant Human TIGIT Protein (Met22-Pro141, A103), C-Fc-tagged | +Inquiry |
TIGIT-729H | Recombinant Human TIGIT Protein, IgG2a Fc-tagged | +Inquiry |
Tigit-149M | Recombinant Mouse Tigit Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
TIGIT-1420MCL | Recombinant Mouse TIGIT cell lysate | +Inquiry |
TIGIT-2610HCL | Recombinant Human TIGIT cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTIGIT inhibitors are being studied in a range of cancers, including lung cancer, breast cancer, and melanoma, among others.
TIGIT is being explored as a potential target for treating autoimmune diseases by modulating immune responses to prevent excessive inflammation.
TIGIT is being explored as a potential target for cancer immunotherapy, with drugs designed to block TIGIT and enhance the immune system's ability to attack cancer cells.
TIGIT operates as an immune checkpoint, similar to PD-1 and CTLA-4, but it has distinct mechanisms of action and may regulate different aspects of the immune response.
As with any immunotherapy, potential side effects may include immune-related adverse events such as inflammation in various organs, but the specific profile is still under investigation.
Customer Reviews (3)
Write a reviewWith its well-characterized nature and availability in various formats, the TIGIT protein is an advantageous tool that aids researchers in achieving their scientific goals.
Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.
The manufacturer also ensures that the TIGIT protein is well-characterized, with extensive documentation on its functional properties.
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