| Description : |
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
104.6 kDa |
| AA Sequence : |
MNLCGLMPIFPAPLDQVADMEELTI WEQHTATLSKDPRRGFGIAISGGRD RPGGSMVVSDVVPGGPAEGRLQTGD HIVMVNGVSMENATSAFAIQILKTC TKMANITVKRPRRIHLPATKASPSS PGRQDSDEDDGPQRVEEVDQGRGYD GDSSSGSGRSWDERSRRPRPGRRGR AGSHGRRSPGGGSEANGLALVSGFK RLPRQDVQMKPVKSVLVKRRDSEEF GVKLGSQIFIKHITDSGLAARHRGL QEGDLILQINGVSSQNLSLNDTRRL IEKSEGKLSLLVLRDRGQFLVNIPP AVSDSDSSPLEEGVTMADEMSSPPA DISDLASELSQAPPSHIPPPPRHAQ RSPEASQTDSPVESPRLRRESSVDS RTISEPDEQRSELPRESSYDIYRVP SSQSMEDRGYSPDTRVVRFLKGKSI GLRLAGGNDVGIFVSGVQAGSPADG QGIQEGDQILQVNDVPFQNLTREEA VQFLLGLPPGEEMELVTQRKQDIFW KMVQSRVGDSFYIRTHFELEPSPPS GLGFTRGDVFHVLDTLHPGPGQSHA RGGHWLAVRMGRDLREQERGIIPNQ SRAEQLASLEAAQRAVGVGPGSSAG SNARAEFWRLRGLRRGAKKTTQRSR EDLSALTRQGRYPPYERVVLREASF KRPVVILGPVADIAMQKLTAEMPDQ FEIAETVSRTDSPSKIIKLDTVRVI AEKDKHALLDVTPSAIERLNYVQYY PIVVFFIPESRPALKALRQWLAPAS RRSTRRLYAQAQKLRKHSSHLFTAT IPLNGTSDTWYQELKAIIREQQTRP IWTAEDQLDGSLEDNLDLPHHGLAD SSADLSCDSRVNSDYETDGEGGAYT DGEGYTDGEGGPYTDVDDEPPAPAL ARSSEPVQADESQSPRDRGRISAHQ GAQVDSRHPQGQWRQDSMRTYEREA LKKKFMRVHDAESSDEDGYDWGPAT DLSGPTRTRRLEQKLISEEDLAAND ILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
