Recombinant Human TMPRSS2 protein, His-tagged
Cat.No. : | TMPRSS2-8077H |
Product Overview : | Recombinant Human TMPRSS2 aa. (Ser284~Gly492) fused with N-terminal His tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Freeze-dried powder |
Molecular Mass : | 27kDa as determined by SDS-PAGE reducing conditions. |
Protein length : | Ser284~Gly492 |
Endotoxin : | <1.0EU per 1ug (determined by the LAL method) |
Purity : | >98% |
Characteristic : | The isoelectric point is 8.2. |
Applications : | SDS-PAGE; WB; ELISA; IP; CoIP; Purification; Amine Reactive Labeling |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Concentration : | 200μg/mL |
Storage Buffer : | 100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5%Trehalose and Proclin300. |
Reconstitution : | Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex. |
Gene Name : | TMPRSS2 transmembrane protease, serine 2 [ Homo sapiens (human) ] |
Official Symbol : | TMPRSS2 |
Synonyms : | PP9284; PRSS10; epitheliasin; serine protease 10; transmembrane protease serine 2 |
Gene ID : | 7113 |
mRNA Refseq : | NM_001135099.1 |
Protein Refseq : | NP_001128571.1 |
UniProt ID : | O15393 |
Products Types
◆ Recombinant Protein | ||
TMPRSS2-05943H | Recombinant Human TMPRSS2 Protein(106-492aa), MBP&His-Avi-tagged, Biotinylated | +Inquiry |
Tmprss2-429R | Recombinant Rat Tmprss2 Protein, His-tagged | +Inquiry |
TMPRSS2-70H | Recombinant Human TMPRSS2 protein, GST-tagged | +Inquiry |
TMPRSS2-05944H | Recombinant Human TMPRSS2 Protein(256-492aa), GST-tagged | +Inquiry |
TMPRSS2-427H | Recombinant Human TMPRSS2 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
TMPRSS2-910HCL | Recombinant Human TMPRSS2 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionYes, transcription factors and signaling pathways have been identified that are associated with the regulation of the expression of TMPRSS2 proteins, which regulate the expression levels and activity of TMPRSS2 proteins.
TMPRSS2 protein can be used to aid the diagnosis of certain tumors. Measuring the expression level of TMPRSS2 proteins in tumor tissues can be used as an auxiliary marker to determine disease type and prognosis.
TMPRSS2 proteins play an important role in some viral infections. For example, in novel coronavirus (SARS-CoV-2) infection, TMPRSS2 proteins facilitate the entry of the virus into host cells.
Yes, proteins that interact with TMPRSS2 proteins have been discovered, including viral proteins, cell surface receptors, etc. These interactions are involved in biological processes such as viral invasion and cell signaling.
Research on TMPRSS2 protein is going on. At present, it mainly focuses on the analysis of its function, the identification of gene mutations associated with diseases, and the interaction with other proteins, providing a theoretical basis for further understanding of diseases related to TMPRSS2 proteins.
Some studies have shown that high expression of TMPRSS2 protein in lung cancer may be associated with a poorer prognosis. However, the specific mechanisms need to be further studied to confirm.
Customer Reviews (3)
Write a reviewStable and did not change significantly during storage and transportation.
High solubility makes it easy to prepare the desired concentration.
The protein had good crystallinity, which was beneficial for crystallographic study.
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