Recombinant Human TNF Protein, His-tagged

Cat.No.: TNF-2001H
Product Overview: Recombinant Human TNF-alpha Protein is produced by E. coli expression system. The target protein is expressed with sequence (Val77-Leu233) of human TNF-alpha (Accession #NP_000585.2) fused with an initial Met at the N-terminus and a 6×His tag at the C-terminus.
Description: This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
Source: E. coli
Species: Human
Tag : His
Form: Lyophilized from sterile PBS, pH 7.4, 5 % trehalose, 5 % mannitol.
Protein length: Val77-Leu233
Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
Purity: > 90% as determined by SDS-PAGE
Stability: Samples are stable for up to twelve months from date of receipt at -70ºC.
Storage: Store it under sterile conditions at -20ºC~-70ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name: tumor necrosis factor [ Homo sapiens (human) ]
Official Symbol: TNF
Synonyms: DIF;TNF-alpha;TNFA;TNFSF2;TNLG1F
Gene ID: 7124
mRNA Refseq: NM_000594.3
Protein Refseq: NP_000585.2
MIM: 191160
UniProt ID: P01375

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