Recombinant Human TNFRSF4
Cat.No. : | TNFRSF4-967H |
Product Overview : | Recombinant human OX40L produced inInsect cellsis a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5 – 25.0 kDa on SDS-PAGE. |
- Specification
- Gene Information
- Related Products
Cat. No. : | TNFRSF4-967H |
Description : | OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between “friend vs. foe” during activation; a mechanism typically termed immuno-tolerance. |
Source : | Insect cells. |
Purity : | > 97%, by SDS-PAGE and HPLC analysis. |
Endotoxin Level : | < 0.1 ng perugof sOX40 Ligand. |
Stabilizer : | None. |
Formulation : | Lyophilized. |
Biological Activity : | Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 30-100 ng/ml. Note: Results may vary with PBMC donors. |
Stability : | The lyophilized protein is stable for at least 2 years from date of receipt at -20℃. Reconstituted sOX40 Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at-20℃. Avoid repeated freeze-thaw cycles. |
Gene Name : | TNFRSF4 tumor necrosis factor receptor superfamily, member 4 [ Homo sapiens ] |
Synonyms : | tumor necrosis factor receptor superfamily, member 4; OX40; ACT35; CD134; TXGP1L; TNFRSF4; tax-transcriptionally activated glycoprotein 1 receptor; lymphoid activation antigene ACT35; OX40 cell surface antigen; OX40 homologue; CD134 antigen; ATC35 antigen; OX40 antigen; OTTHUMP00000001522; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor |
Gene ID : | 7293 |
mRNA Refseq : | NM_003327 |
Protein Refseq : | NP_003318 |
MIM : | 600315 |
UniProt ID : | P43489 |
Chromosome Location : | 1p36 |
Pathway : | Cytokine-cytokine receptor interaction |
Function : | protein binding; receptor activity; tumor necrosis factor receptor activity |
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◆ Lysates | ||
TNFRSF4-2422HCL | Recombinant Human TNFRSF4 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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