| Description : |
This gene belongs to a small gene family whose members have an N-terminal VHS domain followed by a GAT domain; domains which typically participate in vesicular trafficking. The canonical protein encoded by this gene also has a C-terminal clathrin binding motif. This protein has been shown to interact with Tollip, clathrin and ubiquitin and is thought to play a role in endosomal sorting. This gene resides in the 3.7 Mb deletion of chromosome region 17p11.2 that is associated with Smith-Magenis syndrome. Alternative splicing results in multiple transcript variants encoding distinct proteins. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
55.4 kDa |
| AA Sequence : |
MEFLLGNPFSTPVGQCLEKATDGSL QSEDWTLNMEICDIINETEEGPKDA IRALKKRLNGNRNYREVMLALTVLE TCVKNCGHRFHILVANRDFIDSVLV KIISPKNNPPTIVQDKVLALIQAWA DAFRSSPDLTGVVHIYEELKRKGVE FPMADLDALSPIHTPQRSVPEVDPA ATMPRSQSQQRTSAGSYSSPPPAPY SAPQAPALSVTGPITANSEQIARLR SELDVVRGNTKVMSEMLTEMVPGQE DSSDLELLQELNRTCRAMQQRIVEL ISRVSNEEVTEELLHVNDDLNNVFL RYERFERYRSGRSVQNASNGVLNEV TEDNLIDLGPGSPAVVSPMVGNTAP PSSLSSQLAGLDLGTESVSGTLSSL QQCNPRDGFDMFAQTRGNSLAEQRK TVTYEDPQAVGGLASALDNRKQSSE GIPVAQPSVMDDIEVWLRTDLKGDD LEEGVTSEEFDKFLEERAKAAEMVP DLPSPPMEAPAPASNPSGRKKPERS EDALFALTRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
