Recombinant Human Transcription Elongation Factor A (SII), 1, His-tagged
Cat.No. : | TCEA1-6769H |
Product Overview : | Recombinant humanTCEA1 protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Cat. No. : | TCEA1-6769H |
Description : | TCEA1 (Transcriptionelongation factor A protein 1) belongs to the TFS-II family. TCEA1 binds toPol II and functions to cleave the nascent transcript, thereby unlocking thecomplex and allowing transcription to continue. Localized to the nucleus,TCEA1 contains three independently-folding domains, all of which arenecessary for proper binding to Pol II. The arresting sites in DNA have theproperty of trapping a certain fraction of elongating RNA polymerases thatpass through, resulting in locked ternary complexes. Cleavage of the nascenttranscript by S-II allows the resumption of elongation from the new3"-terminus. |
Form : | Liquid. In 20 mMTris-HCl buffer, pH7.5, 20% glycerol, 1mM DTT, 50mM NaCl |
Molecular Weight : | 36.5kDa (325aa),confirmed by MALDI-TOF |
Purity : | > 90% by SDS -PAGE |
Concentration : | 1mg/ml (determinedby Bradford assay) |
Sequences of aminoacids : | MGSSHHHHHHSSGLVPRGSH MGSHMEDEVV RFAKKMDKMV QKKNAAGALD LLKELKNIPM TLELLQSTRI GMSVNAIRKQSTDEEVTSLA KSLIKSWKKL LDGPSTEKDL DEKKKEPAIT SQNSPEAREE STSSGNVSNR KDETNARDTYVSSFPRAPST SDSVRLKCRE MLAAALRTGD DYIAIGADEE ELGSQIEEAI YQEIRNTDMK YKNRVRSRISNLKDAKNPNL RKNVLCGNIP PDLFARMTAE EMASDELKEM RKNLTKEAIR EHQMAKTGGT QTDLFTCGKCKKKNCTYTQV QTRSADEPMT TFVVCNECGN RWKFC |
Storage : | Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Gene Name : | TCEA1transcription elongation factor A (SII), 1 [ Homo sapiens ] |
Official Symbol : | TCEA1 |
Synonyms : | TCEA1; transcription elongationfactor A (SII), 1; GTF2S, TCEA; transcription elongation factor A protein 1;SII; TF2S; TFIIS |
Gene ID : | 6917 |
mRNA Refseq : | NM_006756 |
Protein Refseq : | NP_006747 |
MIM : | 601425 |
Uniprot ID : | P23193 |
Chromosome Location : | 8q11.2 |
Pathway : | DNA Repair, organism-specificbiosystem; Dual incision reaction in TC-NER, organism-specific biosystem;Formation and Maturation of mRNA Transcript, organism-specific biosystem;Formation of HIV-1 elongation complex containing HIV-1 Tat, organism-specificbiosystem; Formation of HIV-1 elongation complex in the absence of HIV-1 Tat,organism-specific biosystem |
Function : | DNA binding; metal ion binding;translation elongation factor activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
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TCEA1-16540M | Recombinant Mouse TCEA1 Protein | +Inquiry |
TCEA1-5980R | Recombinant Rat TCEA1 Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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